激素避孕药和大脑：对人类和动物 60 年来神经影像学、脑电图和生化研究的系统综述。
Hormonal contraceptives and the brain: A systematic review on 60 years of neuroimaging, EEG, and biochemical studies in humans and animals.
机构信息
The Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA; Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA; The Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
D. Samuel Gottesman Library, Albert Einstein College of Medicine, Bronx, NY, USA.
出版信息
Front Neuroendocrinol. 2023 Jan;68:101051. doi: 10.1016/j.yfrne.2022.101051. Epub 2022 Dec 25.
Hormonal contraception has been widely prescribed for decades. Although safety and efficacy are well-established, much uncertainty remains regarding brain effects of hormonal contraception. We systematically review human and animal studies on the brain effects of hormonal contraception which employed neuroimaging techniques such as MRI, PET and EEG, as well as animal studies which reported on neurotransmitter and other brain biochemical effects. We screened 1001 articles and ultimately extracted data from 70, comprising 51 human and 19 animal studies. Of note, there were no animal studies which employed structural or functional MRI, MRS or PET. In summary, our review shows hormonal contraceptive associations with changes in the brain have been documented. Many questions remain and more studies are needed to describe the effects of hormonal contraception on the brain.
激素避孕已广泛应用数十年。尽管其安全性和有效性已得到充分证实，但对于激素避孕对大脑的影响仍存在许多不确定性。我们系统地回顾了人类和动物研究，这些研究采用了 MRI、PET 和 EEG 等神经影像学技术，以及报告了神经递质和其他大脑生化效应的动物研究，以探讨激素避孕对大脑的影响。我们筛选了 1001 篇文章，最终从 70 篇中提取了数据，其中包括 51 项人类研究和 19 项动物研究。值得注意的是，没有采用结构或功能 MRI、MRS 或 PET 的动物研究。总之，我们的综述表明，已经有研究记录了激素避孕药与大脑变化之间的关联。但仍有许多问题亟待解决，需要更多的研究来描述激素避孕对大脑的影响。
Zotero 插件