Phelps T O, Mullane J F
Arch Surg. 1976 Feb;111(2):190-4. doi: 10.1001/archsurg.1976.01360200096019.
Gastric lesions occurred spontaneously and were increased in number by seven hours of restraint stress in rats with portal vein constriction (PVC). Vagotomy and pyloroplasty protected the congested stomach from erosion formation with stress. Major weight loss occurred two days after PVC, but not thereafter. Platelet counts were decreased in intact and splenectomized rats with portal hypertension, but prothrombin time, partial thromboplastin time, and fibrinogen were unaffected, and histological stains failed to demonstrate thrombin in the gastric blood vessels. The oxygen pressure (PO2) of the gastric luminal fluid was decreased at day 2, but was normal at day 4 after PVC. Hypersection of acid and abnormal acid equilibration were not observed in the stomach. Gastric congestion, weight loss, and possibly portasystemic shunting of blood contributed to the higher incidence of gastric erosions with portal hypertension.
门静脉缩窄（PVC）大鼠的胃部病变会自发出现，且在束缚应激7小时后数量会增加。迷走神经切断术和幽门成形术可保护充血的胃部免受应激性糜烂形成的影响。PVC后两天出现明显体重减轻，但此后不再出现。门静脉高压的完整大鼠和脾切除大鼠的血小板计数降低，但凝血酶原时间、部分凝血活酶时间和纤维蛋白原未受影响，组织学染色未在胃血管中显示凝血酶。PVC后第2天胃腔液的氧分压（PO2）降低，但第4天正常。未观察到胃酸分泌过多和酸平衡异常。胃充血、体重减轻以及可能的门体分流导致门静脉高压时胃糜烂的发生率更高。
