University of Bordeaux, INRA, EA 3671, CHU Bordeaux, F-33000, Bordeaux, France.
Gastroenterology and Hepatology Department, Hôpital Haut Lévêque, Centre Hospitalier Universitaire de Bordeaux and Université de Bordeaux, F-33000, Bordeaux, France.
Sleep Breath. 2020 Sep;24(3):971-977. doi: 10.1007/s11325-019-01934-z. Epub 2019 Sep 12.
Sleep is involved in the regulation of inflammation, healing, and digestion. The pathophysiology of Crohn's disease (CD) is unclear, and the role of sleep disturbances has recently been suggested.
The present study investigated a putative association between sleep disturbances and CD activity.
We conducted a prospective observational monocenter translational study, recruiting major CD patients from 2013 to 2015. Disease activity was assessed by the Harvey-Bradshaw index and the CD activity index. Objective sleep quantity and quality were measured by wrist actigraphy over a period of 7 days. The primary objective was to look for an association between wrist actigraphy parameters and CD activity.
Thirty-four CD patients, including 14 with active disease and 20 in remission, were included. Sleep efficiency measured by wrist actigraphy was lower in patients with active CD compared to patients in remission. Wake after sleep onset time best predicted CD activity with an AUROC of 0.83. Patients with active CD were more frequently characterized as "poor sleepers" and frequently suffered from excessive daytime sleepiness.
Sleep efficiency is lower in patients with active CD than in those in remission. Further studies aimed at better characterizing CD patients' sleep are warranted.
睡眠参与炎症、愈合和消化的调节。克罗恩病（CD）的病理生理学尚不清楚，最近有人提出睡眠障碍的作用。
本研究调查了睡眠障碍与 CD 活动之间的潜在关联。
我们进行了一项前瞻性观察性单中心转化研究，从 2013 年到 2015 年招募了主要的 CD 患者。疾病活动度通过 Harvey-Bradshaw 指数和 CD 活动指数评估。通过腕动描记术在 7 天的时间内测量客观的睡眠量和质量。主要目的是寻找腕动描记术参数与 CD 活动之间的关联。
纳入 34 例 CD 患者，其中活动性疾病患者 14 例，缓解期患者 20 例。与缓解期患者相比，腕动描记术测量的睡眠效率在活动性 CD 患者中较低。睡眠后觉醒时间（WASO）是预测 CD 活动的最佳参数，AUROC 为 0.83。活动性 CD 患者更常被定义为“睡眠不佳者”，并经常遭受日间嗜睡。
与缓解期患者相比，活动性 CD 患者的睡眠效率较低。需要进一步研究以更好地描述 CD 患者的睡眠情况。
