Levchenko L I, Promyslov M Sh
Vopr Med Khim. 1979 Sep-Oct;25(5):599-603.
Content of serotonin was distinctly decreased in human brain glial tumors and in transplanted rat gliomas. Activities of 5-hydroxytryptophane decarboxylase and mitochondrial monoamine oxidase were also lowered as compared with the normal state. Content of tryptophane (the main precursor of serotonin) was increased in human and animal tumor tissues; 5-hydroytryptophane was not found in gliomas. A decrease in the tryptophane hydroxylase activity occurred apparently in glioma tissues. The decrease in activity of 5-hydroxytryptorphane decarboxylase, found in tissues of brain glial tumors, might be considered as an adaptive mechanism, since content of serotonin was increased in the tumor tissues after administration of exogenous 5-hydroxytryptophane.
人脑胶质瘤和移植的大鼠胶质瘤中血清素含量明显降低。与正常状态相比，5-羟色氨酸脱羧酶和线粒体单胺氧化酶的活性也降低。色氨酸（血清素的主要前体）在人和动物肿瘤组织中的含量增加；在胶质瘤中未发现5-羟色氨酸。胶质瘤组织中色氨酸羟化酶活性明显降低。在脑胶质瘤组织中发现的5-羟色氨酸脱羧酶活性降低，可能被视为一种适应性机制，因为给予外源性5-羟色氨酸后肿瘤组织中血清素含量增加。
