Baumanis E A, Gorkin V Z, Lisianyĭ N I, Kozhukhov A N
Patol Fiziol Eksp Ter. 1990 Jul-Aug(4):32-5.
A derivative of pyrazinocarbazole the antidepressant pyrazidol, whose inhibition of serotonin deaminase activity of the brain mitochondrial monoamine oxidase is attended by induction of the property of catalysing histamine oxidation, inhibits the growth of glial tumors in experiments. Another derivative of pyrazinocarbazole, which inhibits serotonin deamination but does not induce the appearance of histamine deaminase activity, produces no effect on the growth of glial tumors of the brain.
抗抑郁药吡嗪醇是吡嗪咔唑的衍生物，它对脑线粒体单胺氧化酶的血清素脱氨酶活性的抑制伴随着催化组胺氧化特性的诱导，在实验中可抑制神经胶质瘤的生长。吡嗪咔唑的另一种衍生物，它抑制血清素脱氨基作用，但不诱导组胺脱氨酶活性的出现，对脑胶质细胞瘤的生长没有影响。
