Murugesh Jeevitha, Annigeri Rajeshwari G, Mangala G K, Mythily P Hema, Chandrakala J
Department of Oral Medicine and Radiology, Government Dental College and Research Institute, Bengaluru, Karnataka, India.
Department of Oral Medicine and Radiology, College of Dental Sciences, Davangere, Karnataka, India.
J Oral Maxillofac Pathol. 2019 May-Aug;23(2):305. doi: 10.4103/jomfp.JOMFP_200_18.
Candidal infections have increased significantly in denture wearers, especially in immunocompromised patients. The increase in resistance to existing antifungal drugs and number of patients at risk, in conjunction with the restricted number of commercially available antifungal drugs that still present many side effects, are the cause for this problem. These limitations emphasize the need to develop new and more effective antifungal agents with lesser side effects.
The present study was undertaken to investigate the possible antifungal action of the alcoholic extract of different concentrations of on four dilutions of (1:10, 1:20, 1:40 and 1:80) and to determine its minimum inhibitory concentration (MIC) and minimum fungicidal concentration using Sabouraud's agar medium.
There was complete inhibition of the growth of all four dilutions of at a concentration of 800 μl which is considered as the MIC of alcoholic extract of turmeric on , and the minimum fungicidal concentration was at 1600 μl.
This study indicates a potent antifungal action of against .
念珠菌感染在戴假牙者中显著增加，尤其是在免疫功能低下的患者中。对现有抗真菌药物的耐药性增加以及高危患者数量增多，再加上市面上仍有许多副作用的抗真菌药物数量有限，是导致这个问题的原因。这些局限性凸显了开发新的、更有效的且副作用较小的抗真菌药物的必要性。
本研究旨在调查不同浓度的[具体物质未给出]酒精提取物对[具体物质未给出]的四种稀释液（1:10、1:20、1:40和1:80）的可能抗真菌作用，并使用沙氏琼脂培养基确定其最低抑菌浓度（MIC）和最低杀菌浓度。
在浓度为800微升时，对[具体物质未给出]的所有四种稀释液的生长均有完全抑制，这被认为是姜黄酒精提取物对[具体物质未给出]的MIC，最低杀菌浓度为1600微升。
本研究表明[具体物质未给出]对[具体物质未给出]有强大的抗真菌作用。
