血清白细胞介素-18 水平升高与乳腺癌患者预后不良相关。
High Serum Levels of Interleukin-18 Are Associated With Worse Outcomes in Patients With Breast Cancer.
机构信息
Department of Surgery, Division of Breast and Endocrine Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Laboratory of Tumor Immunology and Cell Therapy, Hyogo College of Medicine, Nishinomiya, Japan.
出版信息
Anticancer Res. 2019 Sep;39(9):5009-5018. doi: 10.21873/anticanres.13691.
BACKGROUND/AIM: Interleukin (IL)-18, which belongs to the IL-1 superfamily of cytokines, is a known interferon-gamma (IFN-γ)-inducing factor. Since IFN-γ plays an essential role in anticancer immunity mediated through cytotoxic T cells, IL-18 may also contribute to the function of immunosurveillance. The aim of the study was to examine the association of IL-18 with the outcomes of patients with breast cancer.
PATIENTS AND METHODS
Serum IL-18 levels were determined at baseline in 270 patients operated for breast cancer, and the relapse-free survival (RFS) was compared between IL-18-high and -low groups. The relationships between IL-18 and tumor-infiltrating lymphocytes (TILs) or the neutrophil-to-lymphocyte ratio (NLR) were also investigated.
RESULTS
The RFS of patients was significantly better in the IL-18-low group than in the IL-18-high group (p=0.032). According to the multivariate analysis, IL-18 was a significant and independent predictive factor for RFS (hazard ratio(HR)=0.336; 95% confidence interval(CI)=0.147-0.727; p=0.0053). No association was observed between the IL-18 levels and TILs or NLRs.
CONCLUSION
IL-18 levels may be useful for predicting the prognosis of patients who have received surgical treatment for breast cancer.
背景/目的：白细胞介素 (IL)-18 属于细胞因子的 IL-1 超家族，是一种已知的干扰素-γ (IFN-γ) 诱导因子。由于 IFN-γ 在通过细胞毒性 T 细胞介导的抗肿瘤免疫中发挥重要作用，IL-18 也可能有助于免疫监视的功能。本研究旨在研究 IL-18 与乳腺癌患者结局的关系。
患者和方法
在 270 例接受乳腺癌手术的患者中，在基线时测定血清 IL-18 水平，并比较 IL-18 高组和低组之间的无复发生存率 (RFS)。还研究了 IL-18 与肿瘤浸润淋巴细胞 (TILs) 或中性粒细胞与淋巴细胞比值 (NLR) 之间的关系。
结果
IL-18 低组患者的 RFS 明显好于 IL-18 高组 (p=0.032)。根据多因素分析，IL-18 是 RFS 的显著独立预测因素 (危险比 (HR)=0.336；95%置信区间 (CI)=0.147-0.727；p=0.0053)。IL-18 水平与 TILs 或 NLR 之间无相关性。
结论
IL-18 水平可能有助于预测接受乳腺癌手术治疗的患者的预后。
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