中性粒细胞与淋巴细胞比值对低肿瘤浸润淋巴细胞的腔面型乳腺癌的预后意义。
Prognostic Significance of Neutrophil-to-lymphocyte Ratio in Luminal Breast Cancers With Low Levels of Tumour-infiltrating Lymphocytes.
机构信息
Department of Surgery, Division of Breast and Endocrine Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
出版信息
Anticancer Res. 2020 May;40(5):2871-2880. doi: 10.21873/anticanres.14263.
BACKGROUND/AIM: This study aimed to improve the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) and tumour-infiltrating lymphocytes (TILs).
PATIENTS AND METHODS
In this retrospective study, NLR and TIL data from 677 operated breast cancer patients were analysed. The cut-off value of NLR was set at 2.72, and TIL levels were classified as low (<10%), intermediate (≥10 to <50%), and high (≥50%).
RESULTS
Recurrence-free survival (RFS) was significantly longer in patients with low NLR (n=459) than in those with high NLR (n=218) (p=0.0383). In ER-positive/HER2-negative and TIL-low breast cancers, there were significant associations between NLR levels and RFS (p=0.0129) or overall survival (OS) (p=0.0046). On multivariate analysis, NLR was a significant and independent factor for OS (hazard ratio=3.78; 95% confidence interval=1.21-14.17; p=0.022).
CONCLUSION
These data may be useful for predicting patient prognosis and understanding the clinical significance of immune status in breast cancers.
背景/目的：本研究旨在提高中性粒细胞与淋巴细胞比值（NLR）和肿瘤浸润淋巴细胞（TIL）的预后意义。
患者与方法
在这项回顾性研究中，分析了 677 例手术乳腺癌患者的 NLR 和 TIL 数据。NLR 的截断值设定为 2.72，TIL 水平分为低（<10%）、中（≥10%至<50%）和高（≥50%）。
结果
无复发生存率（RFS）在 NLR 低（n=459）的患者中明显长于 NLR 高（n=218）的患者（p=0.0383）。在 ER 阳性/HER2 阴性和 TIL 低的乳腺癌中，NLR 水平与 RFS（p=0.0129）或总生存期（OS）（p=0.0046）显著相关。多因素分析显示，NLR 是 OS 的显著独立因素（危险比=3.78；95%置信区间=1.21-14.17；p=0.022）。
结论
这些数据可能有助于预测患者的预后，并了解乳腺癌中免疫状态的临床意义。
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