Department of Surgery, Division of Breast and Endocrine Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
Anticancer Res. 2020 May;40(5):2871-2880. doi: 10.21873/anticanres.14263.
BACKGROUND/AIM: This study aimed to improve the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) and tumour-infiltrating lymphocytes (TILs).
In this retrospective study, NLR and TIL data from 677 operated breast cancer patients were analysed. The cut-off value of NLR was set at 2.72, and TIL levels were classified as low (<10%), intermediate (≥10 to <50%), and high (≥50%).
Recurrence-free survival (RFS) was significantly longer in patients with low NLR (n=459) than in those with high NLR (n=218) (p=0.0383). In ER-positive/HER2-negative and TIL-low breast cancers, there were significant associations between NLR levels and RFS (p=0.0129) or overall survival (OS) (p=0.0046). On multivariate analysis, NLR was a significant and independent factor for OS (hazard ratio=3.78; 95% confidence interval=1.21-14.17; p=0.022).
These data may be useful for predicting patient prognosis and understanding the clinical significance of immune status in breast cancers.
背景/目的：本研究旨在提高中性粒细胞与淋巴细胞比值（NLR）和肿瘤浸润淋巴细胞（TIL）的预后意义。
在这项回顾性研究中，分析了 677 例手术乳腺癌患者的 NLR 和 TIL 数据。NLR 的截断值设定为 2.72，TIL 水平分为低（<10%）、中（≥10%至<50%）和高（≥50%）。
无复发生存率（RFS）在 NLR 低（n=459）的患者中明显长于 NLR 高（n=218）的患者（p=0.0383）。在 ER 阳性/HER2 阴性和 TIL 低的乳腺癌中，NLR 水平与 RFS（p=0.0129）或总生存期（OS）（p=0.0046）显著相关。多因素分析显示，NLR 是 OS 的显著独立因素（危险比=3.78；95%置信区间=1.21-14.17；p=0.022）。
这些数据可能有助于预测患者的预后，并了解乳腺癌中免疫状态的临床意义。
