Institut de Química Avançada de Catalunya (IQAC-CSIC). Jordi Girona 18-26, 08034 Barcelona, Spain. Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain.
Institut de Química Avançada de Catalunya (IQAC-CSIC). Jordi Girona 18-26, 08034 Barcelona, Spain. Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain; Departament de Farmàcia i Tecnologia Farmacèutica i Fisicoquímica. Univ. de Barcelona. Unitat Associada d'I+D al CSIC, IN2UB, Av Joan XXIII, s/n, 08028 Barcelona, Spain.
Carbohydr Polym. 2019 Dec 1;225:115201. doi: 10.1016/j.carbpol.2019.115201. Epub 2019 Aug 13.
Ethylcellulose nano-emulsions have been obtained by the low-energy phase inversion composition method in the Water / [Alkylamidoammonium: Cremophor WO7] / [6% ethylcellulose in ethyl acetate] system at 25 °C. It is shown that nano-emlulsions' composition variables (oil-to-surfactant ratio, cationic: nonionic surfactant ratio and polymer and water content) produce changes in their droplet diameter, surface charge and colloidal stability following defined trends. Nano-emulsions with good stability, droplet diameters between about 120 and 200 nm and surface charge from about 10 to 50 mV have been obtained. Nano-emulsions are further used as templates for nanoparticle dispersions preparation, which show sizes and surface charges typically smaller and similar respectively to their nano-emulsion templates. Cationic: nonionic surfactant ratio has the highest influence on both, size and surface charge, followed by oil-to-surfactant ratio and water content. Interestingly, the positive charge of the nanoparticles can be depleted under diluting conditions in a time-dependent manner.
乙基纤维素纳米乳液已通过低能量相转变组成法在水/[烷基酰胺基铵：吐温 WO7]/[25°C 下的乙酸乙酯中的 6%乙基纤维素]体系中获得。结果表明，纳米乳液的组成变量（油与表面活性剂的比例、阳离子：非离子表面活性剂的比例以及聚合物和水的含量）会使液滴直径、表面电荷和胶体稳定性发生变化，呈现出一定的趋势。已经获得了稳定性良好的纳米乳液，其粒径在约 120nm 至 200nm 之间，表面电荷在约 10mV 至 50mV 之间。纳米乳液进一步用作纳米粒子分散体制备的模板，其粒径和表面电荷通常分别小于和类似于其纳米乳液模板。阳离子：非离子表面活性剂的比例对粒径和表面电荷的影响最大，其次是油与表面活性剂的比例和水含量。有趣的是，纳米粒子的正电荷可以在稀释条件下以时间依赖性的方式耗尽。
