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用于生物医学应用的低能量纳米乳液制备的聚合物纳米颗粒

Polymer nanoparticles from low-energy nanoemulsions for biomedical applications.

作者信息

Grijalvo Santiago, Rodriguez-Abreu Carlos

机构信息

CIBER-BBN, ISCIII, Jordi Girona 18-26, 08034 Barcelona, Spain.

Instituto de Quimica Avanzada de Cataluña (IQAC), CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain.

出版信息

Beilstein J Nanotechnol. 2023 Mar 13;14:339-350. doi: 10.3762/bjnano.14.29. eCollection 2023.

DOI:10.3762/bjnano.14.29
PMID:36959976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10028572/
Abstract

The formulation of nanoemulsions by low-energy strategies, particularly by the phase inversion composition method, and the use of these nanoemulsions as templates for the preparation of polymer nanoparticles for biomedical applications are reviewed. The methods of preparation, nature of the components in the formulation, and their impact on the physicochemical properties, drug loading, and drug release are discussed. We highlight the utilization of ethyl cellulose, poly(lactic--glycolic acid), and polyurethane/polyurea in the field of nanomedicine as potential drug delivery systems. Advances are still needed to achieve better control over size distribution, nanoparticle concentration, surface functionalization, and the type of polymers that can be processed.

摘要

综述了通过低能策略，特别是相转变组成法制备纳米乳液，以及将这些纳米乳液用作模板制备用于生物医学应用的聚合物纳米颗粒的方法。讨论了制备方法、制剂中成分的性质及其对物理化学性质、药物负载和药物释放的影响。我们强调了乙基纤维素、聚（乳酸-乙醇酸）以及聚氨酯/聚脲在纳米医学领域作为潜在药物递送系统的应用。在实现对粒径分布（原文为size distribution，疑有误，可能是particle size distribution）、纳米颗粒浓度、表面功能化以及可加工聚合物类型的更好控制方面仍需取得进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/10028572/4498bb6ff0d0/Beilstein_J_Nanotechnol-14-339-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/10028572/bb759c3267b4/Beilstein_J_Nanotechnol-14-339-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/10028572/bab4aa467fed/Beilstein_J_Nanotechnol-14-339-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/10028572/838946892316/Beilstein_J_Nanotechnol-14-339-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/10028572/49a9bd352e60/Beilstein_J_Nanotechnol-14-339-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/10028572/d0ef22f14dad/Beilstein_J_Nanotechnol-14-339-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/10028572/4498bb6ff0d0/Beilstein_J_Nanotechnol-14-339-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/10028572/bb759c3267b4/Beilstein_J_Nanotechnol-14-339-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/10028572/bab4aa467fed/Beilstein_J_Nanotechnol-14-339-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/10028572/838946892316/Beilstein_J_Nanotechnol-14-339-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/10028572/49a9bd352e60/Beilstein_J_Nanotechnol-14-339-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/10028572/d0ef22f14dad/Beilstein_J_Nanotechnol-14-339-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1955/10028572/4498bb6ff0d0/Beilstein_J_Nanotechnol-14-339-g007.jpg

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