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肥胖患者的术前风险与围手术期管理

[Preoperative risk and perioperative management of obese patients].

作者信息

De Jong A, Verzilli D, Chanques G, Futier E, Jaber S

机构信息

PhyMedExp, University of Montpellier, Inserm, CNRS, CHU Montpellier, 371 avenue du doyen Gaston Giraud, 34080 Montpellier, France; Département d'Anesthésie-Réanimation, hôpital Saint-Éloi, 80, avenue Augustin-Fliche, 34295 Montpellier cedex, France.

Département d'Anesthésie-Réanimation, hôpital Saint-Éloi, 80, avenue Augustin-Fliche, 34295 Montpellier cedex, France.

出版信息

Rev Mal Respir. 2019 Oct;36(8):985-1001. doi: 10.1016/j.rmr.2019.01.009. Epub 2019 Sep 11.

Abstract

The obese patient is at an increased risk of perioperative complications. Most importantly, these include difficult access to the airways (intubation, difficult or impossible ventilation), and post-extubation respiratory distress secondary to the development of atelectasis or obstruction of the airways, sometimes associated with the use of morphine derivatives. The association of obstructive sleep apnea syndrome (OSA) with obesity is very common, and induces a high risk of peri- and postoperative complications. Preoperative OSA screening is crucial in the obese patient, as well as its specific management: use of continuous positive pre, per and postoperative pressure. For any obese patient, the implementation of protocols for mask ventilation and/or difficult intubation and the use of protective ventilation, morphine-sparing strategies and a semi-seated positioning throughout the care, is recommended, combined with close monitoring postoperatively. The dosage of anesthetic drugs should be based on the theoretical ideal weight and then titrated, rather than dosed to the total weight. Monitoring of neuromuscular blocking should be used where appropriate, as well as monitoring of the depth of anesthesia. The occurrence of intraoperative recall is indeed more frequent in the obese patient than in the non-obese patient. Appropriate prophylaxis against venous thromboembolic disease and early mobilization are recommended, as thromboembolic disease is increased in the obese patient. The use of non-invasive ventilation to prevent the occurrence of acute post-operative respiratory failure and for its treatment is particularly effective in obese patients. In case of admission to ICU, an individualized ventilatory management based on pathophysiology and careful monitoring should be initiated.

摘要

肥胖患者围手术期并发症的风险增加。最重要的是,这些并发症包括气道暴露困难(插管、通气困难或无法通气),以及拔管后因肺不张或气道阻塞而继发的呼吸窘迫,有时与吗啡衍生物的使用有关。阻塞性睡眠呼吸暂停综合征(OSA)与肥胖的关联非常常见,并会导致围手术期和术后并发症的高风险。术前对肥胖患者进行OSA筛查至关重要,其特殊管理也很关键:术前、术中和术后使用持续气道正压通气。对于任何肥胖患者,建议实施面罩通气和/或困难插管方案,采用保护性通气、吗啡节约策略,并在整个护理过程中采用半坐位,同时术后密切监测。麻醉药物的剂量应基于理论理想体重,然后进行滴定,而不是根据总体重给药。应在适当情况下使用神经肌肉阻滞监测以及麻醉深度监测。肥胖患者术中知晓的发生率确实比非肥胖患者更高。建议对静脉血栓栓塞性疾病进行适当预防并尽早活动,因为肥胖患者的血栓栓塞性疾病发生率会增加。使用无创通气预防和治疗急性术后呼吸衰竭在肥胖患者中特别有效。如果患者入住重症监护病房(ICU),应根据病理生理学启动个体化通气管理并进行仔细监测。

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