Federal University of Bahia School of Medicine, Salvador, Bahia, Brazil; Immunology Service, University Hospital Professor Edgard Santos, Federal University of Bahia, Salvador, Bahia, Brazil.
Immunology Service, University Hospital Professor Edgard Santos, Federal University of Bahia, Salvador, Bahia, Brazil; Physical Therapy Department, University Hospital Professor Edgard Santos, Federal University of Bahia, Salvador, Bahia, Brazil.
J Sex Med. 2019 Nov;16(11):1763-1768. doi: 10.1016/j.jsxm.2019.07.028. Epub 2019 Sep 11.
Erectile dysfunction (ED) is associated with neurological damage due to human T-lymphotropic virus 1 (HTLV-1) infection, but hormonal and psychogenic factors also cause ED.
To evaluate the association of psychogenic and hormonal factors with ED in men infected with HTLV-1.
In this cross-sectional study, we compared total testosterone, follicle stimulating hormone, luteinizing hormone, prolactin, anxiety symptoms, depressive symptoms, and neurologic manifestations in HTLV-1-infected men with or without ED. The International Index of Erectile Function was used to determine the degree of ED. Participants were grouped according to Osame's Motor Disability Scale and the Expanded Disability Status Scale: HTLV-1-associated myelopathy or tropical spastic paraparesis (HAM/TSP), probable HAM/TSP, or HTLV-1 carrier. Chi-square and Fisher's exact tests were used to compare the groups, and regression analyses were used to show predictors of ED.
Sexual hormonal levels, psychogenic factors, and neurologic disabilities were found to be associated with ED.
ED was associated with age older than 60 years (P < .001), degree of neurologic involvement (P < .001), depression (P = .009), and anxiety (P = .008). In the multivariate analyses, only age and degree of neurological injury remained as risk factors for ED.
Neurological manifestations are a stronger predictor of ED than hormonal and psychogenic factors in HTLV-1-infected men.
STRENGTHS & LIMITATIONS: The statistical power of the study was limited due to the low number of participants, but neurologic manifestations were clearly associated with ED. There was no strong association between hormonal and psychogenic factors and ED.
Hormonal and psychogenic factors did not show a strong association with ED in individuals with HTLV-1, but neurological manifestations were strongly associated with ED in these individuals. de Oliveira CJV, Neto, JAC, Andrade RCP, et al. Hormonal and Psychogenic Risk Factors for Erectile Dysfunction in Men with HTLV-1. J Sex Med 2019; 16:1763-1768.
勃起功能障碍（ED）与人类 T 淋巴细胞病毒 1（HTLV-1）感染引起的神经损伤有关，但激素和心理因素也会导致 ED。
评估心理和激素因素与 HTLV-1 感染男性 ED 的关系。
在这项横断面研究中，我们比较了勃起功能障碍（ED）患者和无 ED 患者的总睾酮、卵泡刺激素、黄体生成素、催乳素、焦虑症状、抑郁症状和神经表现。使用国际勃起功能指数（IIEF）来确定 ED 的严重程度。根据 Osame 运动障碍量表和扩展残疾状况量表，将参与者分为 HTLV-1 相关脊髓病或热带痉挛性截瘫（HAM/TSP）、可能的 HAM/TSP 或 HTLV-1 携带者。采用卡方检验和 Fisher 确切概率法比较各组，采用回归分析显示 ED 的预测因素。
性激素水平、心理因素和神经功能障碍与 ED 有关。
ED 与年龄大于 60 岁（P<0.001）、神经受累程度（P<0.001）、抑郁（P=0.009）和焦虑（P=0.008）有关。多变量分析显示，只有年龄和神经损伤程度仍然是 ED 的危险因素。
在 HTLV-1 感染男性中，神经表现是 ED 的更强预测因素，而不是激素和心理因素。
由于参与者人数较少，研究的统计效力有限，但神经表现与 ED 明显相关。激素和心理因素与 ED 之间没有很强的关联。
在 HTLV-1 个体中，激素和心理因素与 ED 无明显关联，而神经表现与 ED 有很强的关联。
