Balzer Ben W R, Cheng Hoi Lun, Garden Frances, Luscombe Georgina M, Paxton Karen T, Hawke Catherine I, Handelsman David J, Steinbeck Katharine S
Children's Hospital at Westmead, Westmead, Academic Department of Adolescent Medicine, New South Wales, Australia.
University of Sydney, Sydney Medical School Discipline of Child and Adolescent Health, Camperdown, New South Wales, Australia.
Clin Pediatr (Phila). 2019 Nov;58(13):1429-1435. doi: 10.1177/0009922819875531. Epub 2019 Sep 14.
Foot growth is part of overall pubertal growth but its relation to other anthropometric and hormonal changes is unclear. Our objective was to determine how foot length changes relate to changes in other growth parameters (height and weight), Tanner stage, and serum hormones. Adolescents (n = 342) were recruited to a 3-year longitudinal cohort study, underwent annual anthropometric assessments (height, weight, and foot length), and provided self-rated Tanner staging. They also provided blood samples that were analyzed using liquid chromatography-tandem mass spectrometry for serum testosterone and estradiol and classified as pre-pubertal or pubertal based on circulating hormone levels. Average annual percent increase in foot length was greater for pre-pubertal adolescents compared with pubertal. Increased foot length was associated with increases in height, weight, Tanner stage, and serum hormones in males and pre-menarcheal females but not post-menarcheal females. Foot length offers a novel, noninvasive, cost-effective, and easily demonstrable marker of early pubertal changes.
足部生长是青春期整体生长的一部分，但其与其他人体测量学和激素变化之间的关系尚不清楚。我们的目的是确定足长变化与其他生长参数（身高和体重）、坦纳分期以及血清激素变化之间的关系。招募了青少年（n = 342）参加一项为期3年的纵向队列研究，他们每年接受人体测量评估（身高、体重和足长），并进行自我评定的坦纳分期。他们还提供了血液样本，使用液相色谱-串联质谱法分析血清睾酮和雌二醇，并根据循环激素水平分为青春期前或青春期。与青春期青少年相比，青春期前青少年的足长平均年增长率更高。足长增加与男性和月经初潮前女性的身高、体重、坦纳分期以及血清激素增加有关，但与月经初潮后女性无关。足长提供了一种新的、非侵入性的、具有成本效益且易于展示的青春期早期变化标志物。
