Pathobiology and Population Science, The Royal Veterinary College, Hawkshead Lane, Hatfield AL9 7TA, UK.
JKS Bioscience Ltd, 2 Midanbury Court, 44 Midanbury Lane, Southampton SO18 4HF, UK.
Vaccine. 2019 Oct 8;37(43):6241-6247. doi: 10.1016/j.vaccine.2019.09.009. Epub 2019 Sep 12.
During the 2013-2016 Ebola outbreak in West Africa an expert panel was established on the instructions of the UK Prime Minister to identify priority pathogens for outbreak diseases that had the potential to cause future epidemics. A total of 13 priority pathogens were identified, which led to the prioritisation of spending in emerging diseases vaccine research and development from the UK. This meeting report summarises the process used to develop the UK pathogen priority list, compares it to lists generated by other organisations (World Health Organisation, National Institutes of Allergy and Infectious Diseases) and summarises clinical progress towards the development of vaccines against priority diseases. There is clear technical progress towards the development of vaccines. However, the availability of these vaccines will be dependent on sustained funding for clinical trials and the preparation of clinically acceptable manufactured material during inter-epidemic periods.
在 2013 年至 2016 年期间，西非爆发埃博拉疫情，英国首相指示成立一个专家小组，确定有潜力引发未来疫情的爆发性疾病的优先病原体。共确定了 13 种优先病原体，这导致英国在新发疾病疫苗研发方面的支出得到优先考虑。本会议报告总结了制定英国病原体优先清单的过程，将其与其他组织（世界卫生组织、美国国立过敏和传染病研究所）制定的清单进行了比较，并总结了针对优先疾病开发疫苗的临床进展。在疫苗开发方面取得了明显的技术进展。然而，这些疫苗的可用性将取决于临床试验的持续资金投入，以及在疫情间歇期准备临床可接受的成品材料。
