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春季产犊的肉牛所产犊牛中发生先天性甲状腺肿和软骨发育不良疫情。

An outbreak of congenital goiter and chondrodystrophy among calves born to spring-calving beef cows.

作者信息

Homerosky Elizabeth R, Johnsen Megan, Steinmann Mei, Matejka Carling, Jelinski Michael J

机构信息

Veterinary Agri-Health Services Ltd., 201-151 East Lake Blvd. NE, Airdrie, Alberta T4A 2G1 (Homerosky, Johnsen, Jelinski); University of Calgary Faculty of Veterinary Medicine, TRW 2D01, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6 (Steinmann, Matejka).

出版信息

Can Vet J. 2019 Sep;60(9):981-984.

PMID:31523086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6697009/
Abstract

An outbreak of congenital diffuse hyperplastic goiter and chondrodystrophy occurred among springborn calves at an Angus-based cow-calf operation in southern Alberta. Although these diseases are observed globally in multiple species, reports of their occurrence concurrently are exceptionally rare. A nutritional cause is highly suspected as previous matings between the same sires and dams resulted in apparently normal calves. However, it is unclear if multiple mineral deficiencies manifested as goiter and chondrodystrophy independently or if a primary hypothyroidism inhibited normal fetal growth and skeletal development. This is apparently the first large-scale outbreak of concurrent congenital goiter and chondrodystrophy reported in calves.

摘要

在艾伯塔省南部一个以安格斯牛为主的肉牛繁殖场,春季出生的犊牛中爆发了先天性弥漫性增生性甲状腺肿和软骨发育不良。尽管这些疾病在全球多个物种中都有发现,但同时发生的报告极为罕见。由于之前相同公母畜交配产下的犊牛明显正常,因此高度怀疑是营养原因。然而,尚不清楚是多种矿物质缺乏分别表现为甲状腺肿和软骨发育不良,还是原发性甲状腺功能减退抑制了正常的胎儿生长和骨骼发育。这显然是首次报道的犊牛同时发生先天性甲状腺肿和软骨发育不良的大规模疫情。

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本文引用的文献

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J Anim Sci. 2014 May;92(5):2182-91. doi: 10.2527/jas.2013-7481. Epub 2014 Mar 18.
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A novel mutation in the thyroglobulin gene that causes goiter and dwarfism in Wistar Hannover GALAS rats.在 Wistar Hannover GALAS 大鼠中,甲状腺球蛋白基因的一种新突变导致甲状腺肿和侏儒症。
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