采用共面模板辅助的低分割铱源立体定向消融近距离放射疗法治疗周围型肺癌的初步研究

Hypofractionated Ir source stereotactic ablative brachytherapy with coplanar template assistance in the primary treatment of peripheral lung cancer.

作者信息

Pang Haowen, Wu Kui, Shi Xiangxiang, Tang Tao, Sun Xiaoyang, Yang Bo, Wu Jingbo, Lin Sheng

机构信息

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Affiliated Hospital of Southwest Medical University, Luzhou, China.

出版信息

J Contemp Brachytherapy. 2019 Aug;11(4):370-378. doi: 10.5114/jcb.2019.87218. Epub 2019 Aug 29.

PURPOSE

In this study, we reported the safety and efficacy of hypofractionated Ir source stereotactic ablative brachytherapy (SABT) with coplanar template assistance for peripheral lung cancer, and compared the dosimetric parameters between SABT and stereotactic body radiotherapy (SBRT).

MATERIAL AND METHODS

Thirty-three peripheral lung cancer patients, with the gross lung tumor volume (GTVL) < 5 cm in diameter were enrolled in this study. We assessed the safety and efficacy of SABT, and compared the dosimetric parameters between SABT and SBRT.

RESULTS

Chest computed tomography (CT) of post-SABT revealed mild pneumothorax in 2 of 33 patients. Complete response (CR) plus partial response (PR) rate for GTVL at 6-month was 100%. Local control (LC) rate for GTVL at 1-year was 96.9%. For organs at risk (OARs), D1000 cm, and D1500 cm for lung in 1, 3, and 5 fractions were not statistically different between SABT and SBRT (all > 0.05); the remaining dosimetric parameters were significantly lower in SABT than in SBRT (all < 0.01).

CONCLUSIONS

SABT can provide safe and effective treatment, and warrant generalization for peripheral lung cancer.

目的

在本研究中，我们报告了在共面模板辅助下，大分割铱源立体定向消融近距离放射治疗（SABT）用于周围型肺癌的安全性和有效性，并比较了SABT与立体定向体部放射治疗（SBRT）之间的剂量学参数。

材料与方法

本研究纳入了33例直径<5 cm的周围型肺癌患者。我们评估了SABT的安全性和有效性，并比较了SABT与SBRT之间的剂量学参数。

结果

SABT术后胸部计算机断层扫描（CT）显示，33例患者中有2例出现轻度气胸。6个月时GTVL的完全缓解（CR）加部分缓解（PR）率为100%。1年时GTVL的局部控制（LC）率为96.9%。对于危及器官（OARs），SABT与SBRT在1、3和5分次时肺的D1000 cm和D1500 cm无统计学差异（均>0.05）；其余剂量学参数SABT显著低于SBRT（均<0.01）。