White S R
Brain Res. 1979 Nov 9;177(1):157-63. doi: 10.1016/0006-8993(79)90925-9.
Doses of the 5-hydroxytryptamine precursor, 5-hydroxytryptophan, which markedly increased lumbar monosynaptic response (MSR) amplitude in control rats failed to do so in rats paralyzed with experimental allergic encephalomyelitis (EAE). However, lumbar MSR amplitude could be increased in EAE rats just as in control rats by tetanically stimulating the dorsal root. Post-tetanic potentiation of MSR amplitude occurred in the EAE paralyzed rats both prior to and following 5-hydroxytryptophan injection. It was concluded that, as has been reported for the peripheral system in EAE guinea pigs, central nervous system 5-hydroxytryptamine neurotransmission is impaired, at least in the lumbar spinal cord, in EAE rats with hindlimb paralysis.
5-羟色胺前体5-羟色氨酸的剂量，在对照大鼠中可显著增加腰段单突触反应（MSR）的幅度，但在患有实验性变态反应性脑脊髓炎（EAE）而瘫痪的大鼠中却不能。然而，通过强直刺激背根，EAE大鼠的腰段MSR幅度可像对照大鼠一样增加。在5-羟色氨酸注射之前和之后，EAE瘫痪大鼠中均出现了MSR幅度的强直后增强。得出的结论是，正如已报道的EAE豚鼠外周系统的情况一样，在伴有后肢瘫痪的EAE大鼠中，中枢神经系统5-羟色胺神经传递受损，至少在腰段脊髓是如此。
