5-羟色氨酸对大鼠腰脊髓5-羟色胺释放及单突触反应幅度影响的比较

A comparison of 5-hydroxytryptophan effects on rat lumbar spinal cord serotonin release and monosynaptic response amplitude.

作者信息

Samathanam G, Duffy P, Kalivas P W, White S R

机构信息

Department of Veterinary and Comparative Anatomy, Washington State University, Pullman 99164-6520.

出版信息

Brain Res. 1989 Oct 30;501(1):179-82. doi: 10.1016/0006-8993(89)91040-8.

DOI:10.1016/0006-8993(89)91040-8

PMID:2804694

Abstract

The physiological effects of injections of the serotonin precursor, 5-hydroxytryptophan (5-HTP) are thought to result from increased serotonin (5-HT) release, although release has not been directly measured in vivo. This study compared the effects of 5-HTP on rat lumbar spinal cord monosynaptic response (MSR) amplitude and on 5-HT release into lumbar extracellular fluid as measured by in vivo dialysis. 5-HTP significantly increased the amplitude of the MSR and significantly increased the amount of 5-HT in dialysate samples suggesting that 5-HTP enhances the lumbar MSR amplitude by increasing 5-HT release.

摘要

血清素前体5-羟色氨酸（5-HTP）注射的生理效应被认为是血清素（5-HT）释放增加所致，尽管尚未在体内直接测量释放情况。本研究比较了5-HTP对大鼠腰脊髓单突触反应（MSR）幅度以及对通过体内透析测量的腰段细胞外液中5-HT释放的影响。5-HTP显著增加了MSR的幅度，并显著增加了透析液样本中5-HT的含量，表明5-HTP通过增加5-HT释放来增强腰段MSR幅度。