Li Rui, Buchanan Gordon F
Department of Neurology, Carver College of Medicine, University of Iowa, IA, USA.
Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, IA, USA.
Epilepsy Curr. 2019 Nov-Dec;19(6):390-396. doi: 10.1177/1535759719874787. Epub 2019 Sep 16.
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy, accounting for up to 17% of deaths in patients with epilepsy. The pathophysiology of SUDEP has remained unclear, largely because it is unpredictable and commonly unwitnessed. This poses a great challenge to studies in patients. Recently, there has been an increase in animal studies to try to better understand the pathophysiology of SUDEP. In this current review, we focus on developments through seizure-induced death models and the preventative strategies they may reveal.
癫痫猝死(SUDEP)是难治性癫痫患者的主要死因,占癫痫患者死亡人数的17%。SUDEP的病理生理学仍不清楚,主要是因为它不可预测且通常无目击者。这给患者研究带来了巨大挑战。最近,动物研究有所增加,试图更好地了解SUDEP的病理生理学。在本综述中,我们重点关注通过癫痫发作诱导死亡模型取得的进展以及它们可能揭示的预防策略。