Santander Xavier A, Gutiérrez-González Raquel, Cotúa Carlos, Tejerina Eva, Rodríguez Gregorio-Boto
Departments of Neurosurgery.
Departments of Pathology, University Hospital Puerta de Hierro Majadahonda, Madrid, Spain.
Surg Neurol Int. 2019 Jun 25;10:115. doi: 10.25259/SNI-104-2019. eCollection 2019.
The aim of this study is to highlight the importance of cryptococcosis as one of the most common fungal infections of the central nervous system, stressing the consideration of a cryptococcoma within the list of differential diagnosis of intraventricular masses in immunocompetent hosts.
We present the case of an immunocompetent 41-year-old female from Philippines with an intraventricular cryptococcoma due to , mimicking an intraventricular primary brain tumor, who had hydrocephalus. She was approached as having a neoplastic lesion and underwent surgical resection plus third ventriculostomy through endoscopy. Later in her evolution, we realized the infectious nature of the lesion, and antifungal systemic therapy was initiated. In the end, she needed the placement of a ventriculoperitoneal shunt to maintain a good neurologic status. Despite all our efforts, she had a fatal outcome due to various complications.
Our case is the first intraventricular cryptococcoma due to , as far as we know, to be reported in English, German, or Spanish literature. Our report stresses the importance to consider this kind of infection in immunocompetent patients, to raise the level of suspicion of this diagnosis, and to know the complications and management options.
本研究的目的是强调隐球菌病作为中枢神经系统最常见的真菌感染之一的重要性，强调在免疫功能正常宿主的脑室内肿块鉴别诊断清单中应考虑隐球菌瘤。
我们报告一例来自菲律宾的41岁免疫功能正常女性病例，该患者患有由……引起的脑室内隐球菌瘤，酷似脑室内原发性脑肿瘤，并伴有脑积水。她最初被当作肿瘤性病变处理，接受了手术切除并通过内镜进行了第三脑室造瘘术。在其病程后期，我们意识到病变的感染性质，并开始了抗真菌全身治疗。最后，她需要放置脑室腹腔分流管以维持良好的神经状态。尽管我们竭尽全力，但她因各种并发症最终死亡。
据我们所知，我们的病例是首例以英文、德文或西班牙文报道的由……引起的脑室内隐球菌瘤。我们的报告强调了在免疫功能正常的患者中考虑这种感染的重要性，提高对该诊断的怀疑程度，并了解并发症及处理方法。
