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基于量子点的同时多色成像。

Quantum Dot-Based Simultaneous Multicolor Imaging.

机构信息

Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Hubei Key Laboratory of Molecular Imaging, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China.

出版信息

Mol Imaging Biol. 2020 Aug;22(4):820-831. doi: 10.1007/s11307-019-01432-4.

Abstract

Quantum dots have attracted a great deal of attention among researchers in optical imaging because of their unique physicochemical properties. Their adjustable size allows quantum dots to emit visible fluorescence with different wavelengths excited by a single light source, allowing them to play an unmatched role in multitarget simultaneous multicolor imaging of tissues and cells compared with other molecular biotechnologies and traditional fluorescent materials. This technology affords real-time observation in situ of multiple biomarkers, allowing us to quantify their expression levels, and helping us to gain a deeper understanding of the interactions among biomolecules and the relationship between biomolecules and disease occurrence, progression, and prognosis. This has potential to aid in clinical diagnosis and treatment decision making.

摘要

量子点因其独特的物理化学性质,在光学成像研究中引起了极大的关注。它们的可调尺寸使得量子点可以在单个光源激发下发出不同波长的可见荧光,与其他分子生物技术和传统荧光材料相比,它们在组织和细胞的多靶点同时多色成像中发挥着无与伦比的作用。这项技术可以实时原位观察多个生物标志物,定量其表达水平,帮助我们深入了解生物分子之间的相互作用以及生物分子与疾病发生、发展和预后之间的关系。这有助于临床诊断和治疗决策。

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