Noori Z, Moosavian H R, Esmaeilzadeh H, Vali Y, Fazli M
Graduated from Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Department of Clinical Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Iran J Vet Res. 2019 Spring;20(2):151-154.
Autosomal-dominant polycystic kidney disease (ADPKD) is the most prevalent inherited genetic disease of cats, predominantly affecting Persians and Persian-related cats.
The purpose of this study was to determine prevalence of polycystic kidney disease (PKD) in Persian cats in Iran, and also to assess the relationships between PKD and gender, age as well as clinical and paracilinical manifestations.
Sonographic screening examination was performed on all healthy and unhealthy Persian and Persian-related cats referred to Small Animal Hospital of Faculty of Veterinary Medicine, University of Tehran, from April 2014 to May 2015. Cats were classified as positive when at least one anechoic cavity was found in at least one kidney.
Of 76 Persian and Persian-related cats submitted for PKD ultrasound screening, 36.8% were found to have the disease and 63.2% were negative. Therefore, the prevalence of PKD was estimated 36.8% in Persian and Persian related cats in Tehran, Iran, which is approximately similar to prevalence in other parts of the world. Furthermore, there was a significant correlation between PKD and age, as in affected cats the detection probability of renal cysts in sonography was increased in older animals. For each year increase in age, the detection probability of PKD in sonography was increased about 2.62 times.
The prevalence of the PKD amongst Persian cats in Iran is relatively high, and insufficient attention to incidence and prevalence of PKD especially in breeding programs, would spread the disease throughout in Persian cats.
常染色体显性遗传性多囊肾病（ADPKD）是猫最常见的遗传性疾病，主要影响波斯猫及与波斯猫相关的品种。
本研究旨在确定伊朗波斯猫中多囊肾病（PKD）的患病率，并评估PKD与性别、年龄以及临床和亚临床症状之间的关系。
对2014年4月至2015年5月转诊至德黑兰大学兽医学院小动物医院的所有健康和不健康的波斯猫及与波斯猫相关的品种进行超声筛查。当至少一侧肾脏发现至少一个无回声腔时，猫被分类为阳性。
在接受PKD超声筛查的76只波斯猫及与波斯猫相关的品种中，36.8%被发现患有该病，63.2%为阴性。因此，估计伊朗德黑兰波斯猫及与波斯猫相关品种中PKD的患病率为36.8%，这与世界其他地区的患病率大致相似。此外，PKD与年龄之间存在显著相关性，因为在受影响的猫中，年龄较大的动物在超声检查中肾囊肿的检出概率增加。年龄每增加一岁，超声检查中PKD的检出概率增加约2.62倍。
伊朗波斯猫中PKD的患病率相对较高，尤其是在繁殖计划中对PKD的发病率和患病率关注不足，会导致该病在波斯猫中广泛传播。
