Abotorabi Shokohosadat, Mohammadi Masoome, Bagherivand Samira, Oveisi Sonia
Department of Obstetrics and Gynecology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
Department of Metabolic Diseases Research Center, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
Iran J Pharm Res. 2019 Spring;18(2):988-994. doi: 10.22037/ijpr.2017.2040.
Our aim was to examine the effect and cost-effectiveness of isosorbide mononitrate (IMN) for outpatient (at home) cervical ripening in Iranian women with term pregnancy. Term pregnant women were randomly selected to receive either 15 mg vaginally administered IMN or placebo. Patients were advised to take the second dose at home 24 h later and return to the hospital for admission after the next 24 h if the onset of spontaneous contraction does not occur. Cervical status, maternal blood pressure, maternal pulse rate, fetal heart rate and various side effects were examined. IMN induced a significant increase in cervical Bishop Score; headache, nausea, and dizziness were seen in 8 of 28 participants of IMN group; although, all had normal vital signs and normal FHR, they had to be hospitalized and receive medication to relieve the unpleasant symptoms. Vaginal administration of 15 mg of IMN induced cervical ripening in term pregnant women. However, the administration of IMN for cervical ripening is not recommended as it produced headache in significant number of Iranian pregnant women.
我们的目的是研究单硝酸异山梨酯（IMN）对伊朗足月妊娠妇女门诊（在家中）宫颈成熟的效果和成本效益。足月妊娠妇女被随机选择接受阴道给药15mg的IMN或安慰剂。建议患者在24小时后在家中服用第二剂，如果未出现自发宫缩，则在接下来的24小时后返回医院入院。检查宫颈状况、产妇血压、产妇脉搏率、胎儿心率和各种副作用。IMN使宫颈Bishop评分显著增加；IMN组28名参与者中有8人出现头痛、恶心和头晕；尽管所有人生命体征和胎儿心率均正常，但他们不得不住院并接受药物治疗以缓解不适症状。阴道给予15mg的IMN可使足月妊娠妇女宫颈成熟。然而，不建议将IMN用于宫颈成熟，因为它在大量伊朗孕妇中引起了头痛。
