Bolenz C, Rother J, Meessen S, Grychtol B, Majlesara A, Gharabaghi N, Günes C, Ritter M, Deliolanis N, Michel M S, Kriegmair M C
Klinik für Urologie und Kinderurologie, Universitätsklinikum Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Deutschland.
Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Deutschland.
Urologe A. 2019 Dec;58(12):1435-1442. doi: 10.1007/s00120-019-01037-3.
The performance of white light (WL) cystoscopy in the diagnostics of bladder cancer can be optimized by the use of modern imaging modalities, such as photodynamic diagnostics (PDD) and narrow band imaging (NBI). Real-time multispectral imaging (rMSI) enables simultaneous imaging of reflectance and fluorescence modalities in multiple spectral bands. We created a multiparametric cystoscopy image by digital overlapping of several modalities, e.g. WL, enhanced vascular contrast (EVC), raw fluorescence mode, protoporphyrin IX and autofluorescence (AF). The technical development and the subsequent clinical implementation of rMSI required a structured preclinical evaluation process, including both ex vivo and in vivo trials before the technology can be applied in patients. This review article presents the phases of testing, validation and the first clinical application of rMSI in urological endoscopy.
通过使用现代成像方式，如光动力诊断（PDD）和窄带成像（NBI），可以优化白光（WL）膀胱镜检查在膀胱癌诊断中的性能。实时多光谱成像（rMSI）能够在多个光谱带中同时对反射率和荧光模式进行成像。我们通过对多种模式（如WL、增强血管造影（EVC）、原始荧光模式、原卟啉IX和自发荧光（AF））进行数字叠加，创建了一个多参数膀胱镜检查图像。rMSI的技术开发及随后的临床应用需要一个结构化的临床前评估过程，包括在该技术应用于患者之前进行的离体和体内试验。这篇综述文章介绍了rMSI在泌尿外科内镜检查中的测试、验证阶段以及首次临床应用情况。
