Institute for Health & Equity, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
Medical Scientist Training Program, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
Cancer Causes Control. 2019 Dec;30(12):1277-1282. doi: 10.1007/s10552-019-01232-9. Epub 2019 Sep 17.
To calculate tract-level estimates of liver cancer mortality in Wisconsin and identify relationships with racial and socioeconomic variables.
County-level standardized mortality ratios (SMRs) of liver cancer in Wisconsin were calculated using traditional indirect adjustment methods for cases from 2003 to 2012. Tract-level SMRs were calculated using adaptive spatial filtering (ASF). The tract-level SMRs were checked for correlations to a socioeconomic advantage index (SEA) and percent racial composition. Non-spatial and spatial regression analyses with tract-level SMR as the outcome were conducted.
County-level SMR estimates were shown to mask much of the variance within counties across their tracts. Liver cancer mortality was strongly correlated with the percent of Black residents in a census tract and moderately associated with SEA. In the multivariate spatially-adjusted regression analysis, only Percent Black composition remained significantly associated with an increased liver cancer SMR.
Using ASF, we developed a high-resolution map of liver cancer mortality in Wisconsin. This map provided details on the distribution of liver cancer that were inaccessible in the county-level map. These tract-level estimates were associated with several racial and socioeconomic variables.
计算威斯康星州肝癌死亡率的流域级估计值，并确定与种族和社会经济变量的关系。
使用传统的间接调整方法，计算了 2003 年至 2012 年期间威斯康星州各郡肝癌的标准化死亡率比（SMR）。使用自适应空间滤波（ASF）计算流域级 SMR。检查流域级 SMR 与社会经济优势指数（SEA）和种族构成百分比的相关性。使用流域级 SMR 作为结果进行非空间和空间回归分析。
郡级 SMR 估计值表明，在各县内部，各流域之间的差异很大。肝癌死亡率与普查区黑人居民的百分比密切相关，与 SEA 中度相关。在多元空间调整回归分析中，只有黑人比例与肝癌 SMR 升高显著相关。
我们使用 ASF 开发了一张威斯康星州肝癌死亡率的高分辨率地图。该地图提供了在郡级地图中无法获取的肝癌分布详细信息。这些流域级估计值与几个种族和社会经济变量有关。
