State Key Laboratory of Heavy Oil Processing and Centre for Bioengineering and Biotechnology , China University of Petroleum (East China) , Qingdao 266580 , China.
School of Pharmaceutical Science, Key Laboratory of Chemical Biology (Ministry of Education) , Shandong University , 44 West Wenhua Road , Jinan , Shandong 250012 , China.
Langmuir. 2019 Oct 8;35(40):13174-13181. doi: 10.1021/acs.langmuir.9b02513. Epub 2019 Sep 26.
Novel lipopeptide vesicles are prepared from self-assembled nanomembranes through an extrusion method. The size of vesicles can be controlled by the pore diameter of the extrusion filter. The vesicles are rather stable because hydrogen bonds exist among the peptide headgroups. When doxorubicin hydrochloride (DOX·HCl) is encapsulated in the vesicles, it could be released sustainably, and its side effect would also be reduced due to encapsulation. The leakage rate of DOX·HCl depends on the pH via charge regulation. As drug carriers, lipopeptide vesicles have been proved to have nontoxicity to normal cells. A magnetic surfactant CH(CH)CHN(CH) [FeClBr] (CTAFe) was mixed with lipopeptide to modify the vesicles. Also, the results demonstrated that the vesicles is endowed with magnetic property after the addition of CTAFe. We believe that the strategy of lipopeptide vesicle preparation would enrich the drug carrier family and expand the application of lipopeptide materials.
新型脂肽囊泡是通过挤压法从自组装纳米膜中制备的。囊泡的大小可以通过挤压过滤器的孔径来控制。由于肽头基之间存在氢键，囊泡相当稳定。当盐酸阿霉素 (DOX·HCl) 被包裹在囊泡中时，它可以持续释放，并且由于包裹而减少了副作用。DOX·HCl 的泄漏率通过电荷调节取决于 pH 值。作为药物载体，脂肽囊泡已被证明对正常细胞没有毒性。将磁性表面活性剂 CH(CH)CHN(CH) [FeClBr] (CTAFe) 与脂肽混合以修饰囊泡。此外，结果表明，加入 CTAFe 后，囊泡具有磁性。我们相信，脂肽囊泡制备策略将丰富药物载体家族，并扩展脂肽材料的应用。
