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磁性纳米颗粒在细胞治疗中的应用。

Application of magnetic nanoparticles in cell therapy.

机构信息

Institute of Disaster and Emergency Medicine, Tianjin University, Tianjin, China.

Tianjin Key Laboratory of Disaster Medicine Technology, Tianjin, China.

出版信息

Stem Cell Res Ther. 2022 Apr 1;13(1):135. doi: 10.1186/s13287-022-02808-0.

DOI:10.1186/s13287-022-02808-0
PMID:35365206
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8972776/
Abstract

FeO magnetic nanoparticles (MNPs) are biomedical materials that have been approved by the FDA. To date, MNPs have been developed rapidly in nanomedicine and are of great significance. Stem cells and secretory vesicles can be used for tissue regeneration and repair. In cell therapy, MNPs which interact with external magnetic field are introduced to achieve the purpose of cell directional enrichment, while MRI to monitor cell distribution and drug delivery. This paper reviews the size optimization, response in external magnetic field and biomedical application of MNPs in cell therapy and provides a comprehensive view.

摘要

FeO 磁性纳米颗粒（MNPs）是已获得 FDA 批准的生物医学材料。迄今为止，MNPs 在纳米医学中发展迅速，具有重要意义。干细胞和分泌小泡可用于组织再生和修复。在细胞治疗中，引入与外部磁场相互作用的 MNPs 以实现细胞定向富集的目的，同时通过 MRI 监测细胞分布和药物递送。本文综述了 MNPs 在细胞治疗中的尺寸优化、对外磁场的响应及生物医学应用，提供了全面的观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/8973556/d47673c94a84/13287_2022_2808_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/8973556/82e10a6192c8/13287_2022_2808_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/8973556/d47673c94a84/13287_2022_2808_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/8973556/82e10a6192c8/13287_2022_2808_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1f/8973556/d47673c94a84/13287_2022_2808_Fig2_HTML.jpg

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[7]
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[9]
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[10]
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本文引用的文献

[1]
Designer exosomes enabling tumor targeted efficient chemo/gene/photothermal therapy.

Biomaterials. 2021-9

[2]
Targeted extracellular vesicle delivery systems employing superparamagnetic iron oxide nanoparticles.

Acta Biomater. 2021-10-15

[3]
Bone mesenchymal stem cells stimulation by magnetic nanoparticles and a static magnetic field: release of exosomal miR-1260a improves osteogenesis and angiogenesis.

J Nanobiotechnology. 2021-7-13

[4]
Treatment of infarcted heart tissue via the capture and local delivery of circulating exosomes through antibody-conjugated magnetic nanoparticles.

Nat Biomed Eng. 2020-11

[5]
Exosomes Derived from Bone Mesenchymal Stem Cells with the Stimulation of FeO Nanoparticles and Static Magnetic Field Enhance Wound Healing Through Upregulated miR-21-5p.

Int J Nanomedicine. 2020-10-19

[6]
Magnetic targeting enhances the cutaneous wound healing effects of human mesenchymal stem cell-derived iron oxide exosomes.

J Nanobiotechnology. 2020-8-14

[7]
Targeted Delivery of Mesenchymal Stem Cell-Derived Nanovesicles for Spinal Cord Injury Treatment.

Int J Mol Sci. 2020-6-11

[8]
Magnetic targeting increases mesenchymal stromal cell retention in lungs and enhances beneficial effects on pulmonary damage in experimental silicosis.

Stem Cells Transl Med. 2020-10

[9]
Ultrasound monitoring of magnet-guided delivery of mesenchymal stem cells labeled with magnetic lipid-polymer hybrid nanobubbles.

Biomater Sci. 2020-7-7

[10]
Nanovesicles derived from iron oxide nanoparticles-incorporated mesenchymal stem cells for cardiac repair.

Sci Adv. 2020-5

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