一名2岁男童患嗅神经母细胞瘤（嗅感觉神经母细胞瘤）。

Olfactory neuroblastoma (esthesioneuroblastoma) in a 2-year-old boy.

作者信息

Woerner S J, Lazerson J, Munn R J, Turner E A

机构信息

Department of Pediatrics and Pathology, School of Medicine, University of California, Davis 95817.

出版信息

Pediatr Hematol Oncol. 1986;3(2):167-74. doi: 10.3109/08880018609031213.

DOI:10.3109/08880018609031213

PMID:3153227

Abstract

A 2-year-old boy presented with sudden blindness and epistaxis resulting from olfactory neuroblastoma with intracranial extension. This disease is uncommon in children, with only 27 cases reported in patients less than 17 years of age. This article reviews the clinical and histological features of this tumor and discusses treatment. Therapy has generally consisted of surgery and radiation. Our child and 2 others treated with radiation and combination chemotherapy (including cyclophosphamide and anthracyclines) have done well with follow-ups of up to 9 1/2 years. Chemotherapy is an important form of adjuvant therapy in this disease.

摘要

一名2岁男童因嗅神经母细胞瘤伴颅内扩展出现突然失明和鼻出血。这种疾病在儿童中并不常见，17岁以下患者仅报告过27例。本文回顾了该肿瘤的临床和组织学特征并讨论了治疗方法。治疗通常包括手术和放疗。我们的患儿以及另外2名接受放疗和联合化疗（包括环磷酰胺和蒽环类药物）的患儿，在长达9年半的随访中情况良好。化疗是这种疾病重要的辅助治疗形式。