Tian C X, Li L, Qiu P, Qiu Y R
Laboratory Medicine Centre, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Department of Clinical Laboratory Science, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, P.R. China.
Br J Biomed Sci. 2020 Jan;77(1):24-28. doi: 10.1080/09674845.2019.1666783. Epub 2019 Oct 21.
: Specific single-nucleotide polymorphisms (SNPs) in the M-type phospholipase A2 receptor-1 () are associated with increased risk of idiopathic membranous nephropathy (IMN) in European populations. We hypothesized links between IMN and SMN with these SNPs in two Chinese cohorts.: A cohort of 166 IMN patients and 144 controls from southern China (Group A) and a cohort of 212 IMN patients, 118 SMN patients, and 162 controls from northwestern China (Group B) were recruited. SNPs within (rs3749119, rs3749117, rs35771982, rs3828323, and rs4664308) were identified and the frequencies of genotypes and alleles were determined for the different groups.: Relative to controls, IMN patients had a greater prevalence of rs35771982, rs3749117, and rs4664308 in Group A (OR = 1.61, 95% CI = 1.13-2.31, = 0.011; OR = 1.62 (1.15-2.29), = 0.006 and OR = 1.17 (1.06-1.28), = 0.001, respectively) and in Group B (OR = 1.58 (1.13-2.22), = 0.009; OR = 1.68 (1.22-2.33), = 0.002 and OR = 1.15 (1.06-1.25), < 0.001, respectively). Genotype and allele distributions of rs4664308 differed significantly between SMN patients and controls in Group B (OR = 1.58 (1.10-2.26), = 0.012). Genotype and allele distribution of rs35771982 and rs4664308 differed significantly between PLA2R-Ab(+) and PLA2R-Ab(-) IMN patients in Group B (OR = 1.59 (1.09-2.31), = 0.018 and OR = 1.15 (1.03-1.29), = 0.005, respectively).: This study of two cohorts from different regions of China indicate that specific polymorphisms are associated with IMN and SMN.
M型磷脂酶A2受体1（）中的特定单核苷酸多态性（SNP）与欧洲人群特发性膜性肾病（IMN）风险增加相关。我们推测在中国的两个队列中，这些SNP与IMN和SMN之间存在联系。
招募了来自中国南方的166例IMN患者和144例对照（A组），以及来自中国西北的212例IMN患者、118例SMN患者和162例对照（B组）。确定了（rs3749119、rs3749117、rs35771982、rs3828323和rs4664308）内的SNP，并测定了不同组的基因型和等位基因频率。
与对照组相比，A组中rs35771982、rs3749117和rs4664308在IMN患者中的患病率更高（OR = 1.61，95% CI = 1.13 - 2.31， = 0.011；OR = 1.62（1.15 - 2.29）， = 0.006；OR = 1.17（1.06 - 1.28）， = 0.001），B组中（OR = 1.58（1.13 - 2.22）， = 0.009；OR = 1.68（1.22 - 2.33）， = 0.002；OR = 1.15（1.06 - 1.25）， < 0.001）。B组中，rs4664308的基因型和等位基因分布在SMN患者和对照组之间存在显著差异（OR = 1.58（1.10 - 2.26）， = 0.012）。B组中，rs35771982和rs4664308的基因型和等位基因分布在PLA2R - Ab(+)和PLA2R - Ab(-)的IMN患者之间存在显著差异（OR = 1.59（1.09 - 2.31）， = 0.018；OR = 1.15（1.03 - 1.29）， = 0.005）。
这项对来自中国不同地区的两个队列的研究表明，特定的多态性与IMN和SMN相关。
