Qiu Jing Yi, Wu Xuan Gao, Zhang Ting, Park Sunmin
Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo University, Asan, South Korea.
Medicine (Baltimore). 2020 Nov 6;99(45):e22908. doi: 10.1097/MD.0000000000022908.
Previous studies have evaluated the association between the phospholipase A2 m-type receptor (PLA2R1) rs4664308 polymorphism and the risk of idiopathic membranous nephropathy (IMN), but the results need to be integrated. We hypothesized that the PLA2R1 rs4664308 polymorphism is associated with IMN risk in different ethnicities and assessed this hypothesis by using meta-analysis and case-control studies.A literature searches on PLA2R1 rs4664308 and IMN risk was conducted using the EMBASE, PubMed, Cochrane Library, and Chinese Medical Databases. The relationship between PLA2R1 rs4664308 and IMN risk was evaluated in 5 genetic models, namely, allelic (AG), recessive (RG), dominant (DG), homozygous (HMG), and heterozygous (HTG) models. Subgroup analysis was conducted by ethnicity on Asian and non-Asian populations.Eight sets of data from 6 articles met study objectives were selected and 6797 subjects (IMN: 2324 Controls: 4,473) were included. Heterogeneity was found in the DG, HMG, and HTG models but not in the AG or RG models. The minor allele(G) of PLA2R1 rs4664308 showed a significant negative correlation with IMN risk in all genetic random models: odds ratio of AG: 0.44(0.37-0.51), RG: 0.35(0.29-0.42), DG: 0.38(0.31-0.48), HMG: 0.26(0.19-0.37), and HTG: 0.61(0.48-0.77; P < .00001), and Asians and non-Asians showed the same effect of PLA2R1 rs4664308 on IMN risk. Analysis of Asians and non-Asians revealed no publication bias in any of the 5 genetic models.The minor allele of PLA2R1 rs4664308 has a protective activity against IMN in Asians and non-Asians. It provided new insights into potential curative and preventative treatments for IMN.
以往的研究评估了磷脂酶A2 m型受体（PLA2R1）rs4664308多态性与特发性膜性肾病（IMN）风险之间的关联，但结果需要整合。我们假设PLA2R1 rs4664308多态性与不同种族的IMN风险相关，并通过荟萃分析和病例对照研究来评估这一假设。使用EMBASE、PubMed、Cochrane图书馆和中国医学数据库对PLA2R1 rs4664308和IMN风险进行了文献检索。在5种遗传模型中评估了PLA2R1 rs4664308与IMN风险之间的关系，即等位基因（AG）、隐性（RG）、显性（DG）、纯合子（HMG）和杂合子（HTG）模型。按种族对亚洲和非亚洲人群进行亚组分析。从6篇符合研究目标的文章中选取了8组数据，纳入6797名受试者（IMN：2324例；对照：4473例）。在DG、HMG和HTG模型中发现了异质性，但在AG或RG模型中未发现。PLA2R1 rs4664308的次要等位基因（G）在所有遗传随机模型中均与IMN风险呈显著负相关：AG的优势比为0.44（0.37 - 0.51），RG为0.35（0.29 - 0.42），DG为0.38（0.31 - 0.48），HMG为0.26（0.19 - 0.37），HTG为0.61（0.48 - 0.77；P＜0.00001），亚洲人和非亚洲人显示PLA2R1 rs4664308对IMN风险的影响相同。对亚洲人和非亚洲人的分析显示，在5种遗传模型中的任何一种中均未发现发表偏倚。PLA2R1 rs4664308的次要等位基因对亚洲人和非亚洲人的IMN具有保护作用。它为IMN的潜在治疗和预防提供了新的见解。
