Orgel Etan, Sea Jessica L, Mittelman Steven D
Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, CA Department of Pediatrics, Keck School of Medicine, University of Southern California.
Division of Pediatric Endocrinology, UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine UCLA, Los Angeles, CA.
J Natl Cancer Inst Monogr. 2019 Sep 1;2019(54):152-156. doi: 10.1093/jncimonographs/lgz020.
The prevalence of obesity has steadily risen over the past decades, even doubling in more than 70 countries. High levels of body fat (adiposity) and obesity are associated with endocrine and hormonal dysregulation, cardiovascular compromise, hepatic dysfunction, pancreatitis, changes in drug metabolism and clearance, inflammation, and metabolic stress. It is thus unsurprising that obesity can affect the development of and survival from a wide variety of malignancies. This review focuses on acute lymphoblastic leukemia, the most common malignancy in children, to explore the multiple mechanisms connecting acute lymphoblastic leukemia, obesity, and adipocytes, and the implications for leukemia therapy.
在过去几十年中，肥胖症的患病率稳步上升，在70多个国家甚至翻了一番。高水平的体脂（肥胖）与内分泌和激素失调、心血管功能损害、肝功能障碍、胰腺炎、药物代谢和清除的变化、炎症以及代谢应激相关。因此，肥胖会影响多种恶性肿瘤的发生发展和生存也就不足为奇了。本综述聚焦于儿童最常见的恶性肿瘤——急性淋巴细胞白血病，探讨连接急性淋巴细胞白血病、肥胖症和脂肪细胞的多种机制，以及对白血病治疗的影响。
