Department of Food Science & Technology, Chonnam National University, Gwangju, 61186, Republic of Korea.
College of Pharmacy, Chonnam National University, Gwangju, 61186, Republic of Korea.
Chem Biodivers. 2019 Oct;16(10):e1900347. doi: 10.1002/cbdv.201900347. Epub 2019 Sep 18.
Catechins in green tea are well-known to be effective in reducing the risk of obesity. The purpose of this study was to elucidate the effects of catechins present in green tea on adipocyte differentiation and mature adipocyte metabolism. Treatment of 3T3-L1 mouse adipocyte during differentiation adipocytes with (-)-epigallocatechin (EGC) and gallic acid (GA) resulted in dose-dependent inhibition of adipogenesis. Specifically, EGC increased adiponectin and uncoupling protein 1 (UCP1) transcription in mature adipocytes. Transcription levels of adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) were not significantly impacted by either of the compounds. These results suggest that the EGC is the most effective catechin having anti-obesity activity. Finally, EGC is an attractive candidate component for remodeling obesity.
绿茶中的儿茶素是众所周知的有效降低肥胖风险。本研究旨在阐明绿茶中儿茶素对脂肪细胞分化和成熟脂肪细胞代谢的影响。用（-）-表没食子儿茶素（EGC）和没食子酸（GA）处理 3T3-L1 小鼠脂肪细胞分化过程中的脂肪细胞，结果显示儿茶素呈剂量依赖性地抑制脂肪生成。具体来说，EGC 增加了成熟脂肪细胞中脂联素和解偶联蛋白 1（UCP1）的转录。两种化合物对脂肪甘油三酯脂肪酶（ATGL）和激素敏感脂肪酶（HSL）的转录水平没有显著影响。这些结果表明，EGC 是最有效的具有抗肥胖活性的儿茶素。最后，EGC 是重塑肥胖的有吸引力的候选成分。
