Basu Tanisha, Selman Ashley, Reddy Arubala P, Reddy P Hemachandra
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Nutritional Sciences Department, College of Human Sciences, Texas Tech University, Lubbock, TX 79409, USA.
Antioxidants (Basel). 2023 Feb 13;12(2):474. doi: 10.3390/antiox12020474.
Obesity is a growing health concern in today's society. Current estimates indicate that obesity occurs in both adults and young people. Recent research also found that the Hispanic population in the U.S. is 1.9 times more likely to be overweight as compared to their non-Hispanic population. Obesity is a multifactorial disease that has a variety of causes. All current treatment options incorporate dietary changes aimed at establishing a negative energy balance. According to current scientific research, multiple factors are involved with the development of obesity, including genetic, biochemical, psychological, environmental, behavioral, and socio-demographic factors. The people who suffer from obesity are far more likely to suffer serious health problems, such as stroke, diabetes, lung disease, bone and joint disease, cancer, heart disease, neurological disorders, and poor mental health. Studies indicate that multiple cellular changes are implicated in the progression of obesity, mitochondrial dysfunction, deregulated microRNAs, inflammatory changes, hormonal deregulation, and others. This article highlights the role that oxidative stress plays in obesity and current obesity-prevention techniques with an emphasis on the impact of catechins to prevent and treat obesity.
肥胖是当今社会日益严重的健康问题。目前的估计表明，肥胖在成年人和年轻人中都有发生。最近的研究还发现，美国的西班牙裔人口超重的可能性是非西班牙裔人口的1.9倍。肥胖是一种多因素疾病，有多种病因。目前所有的治疗方案都包括旨在建立负能量平衡的饮食改变。根据目前的科学研究，肥胖的发生涉及多种因素，包括遗传、生化、心理、环境、行为和社会人口因素。肥胖者更容易患上严重的健康问题，如中风、糖尿病、肺病、骨和关节疾病、癌症、心脏病、神经紊乱和心理健康不佳。研究表明，多种细胞变化与肥胖的进展、线粒体功能障碍、微小RNA失调、炎症变化、激素失调等有关。本文重点介绍氧化应激在肥胖中的作用以及当前的肥胖预防技术，特别强调儿茶素对预防和治疗肥胖的影响。
