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高钾含量解释了山黧豆种子提取物在体外对两栖类坐骨神经动作电位的消除作用。

High K+ content explains the abolition of the action potential in amphibian sciatic nerve in vitro by Lathyrus sativus seed extract.

作者信息

Pearson S, Nunn P B, Abbott N J

出版信息

Experientia. 1979 Oct 15;35(10):1363-4. doi: 10.1007/BF01964010.

DOI:10.1007/BF01964010
PMID:315330
Abstract

The action potential in amphibian sciatic nerve in vitro has been reported to be abolished by the topical application of Lathyrus sativus seed extract. We have confirmed this effect, but find that it is probably caused by the high K+ content of such seed extracts and that organic neurotoxins are not implicated.

摘要

据报道，在体外，山黧豆种子提取物局部应用于两栖动物坐骨神经时可消除动作电位。我们已经证实了这种效应，但发现这可能是由于此类种子提取物中高钾含量所致，而非有机神经毒素的作用。

相似文献

1
High K+ content explains the abolition of the action potential in amphibian sciatic nerve in vitro by Lathyrus sativus seed extract.高钾含量解释了山黧豆种子提取物在体外对两栖类坐骨神经动作电位的消除作用。
Experientia. 1979 Oct 15;35(10):1363-4. doi: 10.1007/BF01964010.
2
Differential effects of tetrodotoxin (TTX) and high external K+ on A and C fibre compound action potential peaks in frog sciatic nerve.
Neurosci Lett. 1996 Nov 22;219(2):131-4. doi: 10.1016/s0304-3940(96)13189-x.
3
[Role of potassium and calcium ions in eliciting the fiber interaction effect in the frog nerve trunk].[钾离子和钙离子在引发青蛙神经干纤维相互作用效应中的作用]
Dokl Akad Nauk SSSR. 1972 Jul 21;205(3):742-4.
4
Effects of nerve blocking agents on fast axonal transport of proteins in frog sciatic nerves in vitro.神经阻滞剂对体外培养的青蛙坐骨神经中蛋白质快速轴突运输的影响。
Brain Res. 1973 Feb 14;50(1):125-34. doi: 10.1016/0006-8993(73)90599-4.
5
The effects of gallamine on nerve terminals and endplates.加拉明对神经末梢和终板的作用。
Anesthesiology. 1973 Feb;38(2):157-65. doi: 10.1097/00000542-197302000-00011.
6
The effect of "non-tai-yak" (Stemona curtisii) on the action potential of isolated frog sciatic nerve. A preliminary report.“非大葉百部”（庫氏百部）對離體青蛙坐骨神經動作電位的影響。初步報告。
J Med Assoc Thai. 1985 Feb;68(2):66-71.
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The local anaesthetic activity of metiamide, a histamine H2- receptor antagonist.甲硫米特（一种组胺H2受体拮抗剂）的局部麻醉活性。
J Pharm Pharmacol. 1977 Apr;29(4):244-5. doi: 10.1111/j.2042-7158.1977.tb11299.x.
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Physiological and biochemical changes in frog sciatic nerve during anoxia and recovery.缺氧及恢复过程中青蛙坐骨神经的生理和生化变化
J Neurochem. 1971 Dec;18(12):2335-53. doi: 10.1111/j.1471-4159.1971.tb00189.x.
9
Frequency-dependent conduction block: the role of nerve impulse pattern in local anesthetic potency.
Anesthesiology. 1978 Feb;48(2):111-7.
10
Neuromuscular blocking effects of an alkaloidal extract from Inula royleana: contractile and electrical studies on amphibian skeletal muscle in vitro.土木香生物碱提取物对神经肌肉的阻滞作用：两栖类骨骼肌体外收缩及电生理研究
Indian J Physiol Pharmacol. 2000 Apr;44(2):143-52.

本文引用的文献

1
Effect of potassium and sodium on resting and action potentials of single myelinated nerve fibers.钾和钠对单根有髓神经纤维静息电位和动作电位的影响。
J Physiol. 1951 Feb;112(3-4):496-508. doi: 10.1113/jphysiol.1951.sp004546.
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TOXIC FACTORS IN LATHYRUS SATIVUS.山黧豆中的毒性因子。
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THE ISOLATION AND CHARACTERIZATION OF BETA-N-OXALYL-L-ALPHA,BETA-DIAMINOPROPIONIC ACID: A NEUROTOXIN FROM THE SEEDS OF LATHYRUS SATIVUS.β-N-草酰-L-α,β-二氨基丙酸的分离与特性：一种来自山黧豆种子的神经毒素。
Biochemistry. 1964 Mar;3:432-6. doi: 10.1021/bi00891a022.
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[Amino acid determination on paper chromatograms].[纸色谱法测定氨基酸]
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Lathyrism.山黧豆中毒
Rev Can Biol. 1957 Apr;16(1):1-82.
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The membrane resting and action potentials of the cat auricle.猫耳廓的膜静息电位和动作电位。
J Physiol. 1953 Feb 27;119(2-3):139-52. doi: 10.1113/jphysiol.1953.sp004834.
7
Lathyrism: a review.山黧豆中毒：综述
Q Rev Biol. 1974 Jun;49(2):101-28. doi: 10.1086/408017.
8
Entry of beta-N-oxalyl-L-alpha,beta-diaminopropionic acid, the Lathyrus sativus neurotoxin into the central nervous system of the adult rat, chick and the rhesus monkey.
J Neurochem. 1978 Jun;30(6):1467-70. doi: 10.1111/j.1471-4159.1978.tb10479.x.