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Entry of beta-N-oxalyl-L-alpha,beta-diaminopropionic acid, the Lathyrus sativus neurotoxin into the central nervous system of the adult rat, chick and the rhesus monkey.

作者信息

Rao S L

出版信息

J Neurochem. 1978 Jun;30(6):1467-70. doi: 10.1111/j.1471-4159.1978.tb10479.x.

DOI:10.1111/j.1471-4159.1978.tb10479.x
PMID:97367
Abstract
摘要

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1
Entry of beta-N-oxalyl-L-alpha,beta-diaminopropionic acid, the Lathyrus sativus neurotoxin into the central nervous system of the adult rat, chick and the rhesus monkey.
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Genotypic Variation in the Concentration of β-N-Oxalyl-L-α,β-diaminopropionic Acid (β-ODAP) in Grass Pea (Lathyrus sativus L.) Seeds Is Associated with an Accumulation of Leaf and Pod β-ODAP during Vegetative and Reproductive Stages at Three Levels of Water Stress.在三种水分胁迫水平下，在营养生长和生殖生长阶段，菜豆（Lathyrus sativus L.）种子中β-N-草酰基-L-α，β-二氨基丙酸（β-ODAP）浓度的基因型变异与叶片和豆荚中β-ODAP 的积累有关。
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In vivo metabolism of beta-N-oxalyl-L-alpha,beta-diaminopropionic acid: the Lathyrus sativus neurotoxin in experimental animals.
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The Lathyrus sativus neurotoxin: evidence of selective retention in monkey tissue.
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Receptor interactions of beta-N-oxalyl-L-alpha,beta-diaminopropionic acid, the Lathyrus sativus putative excitotoxin, with synaptic membranes.山黧豆潜在兴奋性毒素β-N-草酰-L-α,β-二氨基丙酸与突触膜的受体相互作用。
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J Neurochem. 1976 Dec;27(6):1327-31. doi: 10.1111/j.1471-4159.1976.tb02611.x.

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In vitro activation of protein kinase C by beta-N-oxalyl-L-alpha,beta-diaminopropionic acid, the Lathyrus sativus neurotoxin.β-N-草酰-L-α,β-二氨基丙酸（即香豌豆神经毒素）对蛋白激酶C的体外激活作用。
Neurochem Res. 2004 Jul;29(7):1343-8. doi: 10.1023/b:nere.0000026395.25468.57.
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Neurotoxic potential of three structural analogs of beta-N-oxalyl-alpha,beta-diaminopropanoic acid (beta-ODAP).β-N-草酰-α,β-二氨基丙酸（β-ODAP）三种结构类似物的神经毒性潜力。
Neurochem Res. 1999 Jun;24(6):791-7. doi: 10.1023/a:1020791815848.
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Thiol oxidation and loss of mitochondrial complex I precede excitatory amino acid-mediated neurodegeneration.硫醇氧化和线粒体复合物I的丧失先于兴奋性氨基酸介导的神经退行性变。
J Neurosci. 1998 Dec 15;18(24):10287-96. doi: 10.1523/JNEUROSCI.18-24-10287.1998.
7
Effect of beta-N-oxalylamino-L-alanine on cerebellar cGMP level in vivo.
Neurochem Res. 1993 Feb;18(2):171-5. doi: 10.1007/BF01474681.
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Lathyrus excitotoxin: mechanism of neuronal excitation by L-2-oxalylamino-3-amino- and L-3-oxalylamino-2-amino-propionic acid.
Exp Brain Res. 1984;57(1):158-66. doi: 10.1007/BF00231142.
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High K+ content explains the abolition of the action potential in amphibian sciatic nerve in vitro by Lathyrus sativus seed extract.高钾含量解释了山黧豆种子提取物在体外对两栖类坐骨神经动作电位的消除作用。
Experientia. 1979 Oct 15;35(10):1363-4. doi: 10.1007/BF01964010.