The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Immunity. 2019 Sep 17;51(3):426-428. doi: 10.1016/j.immuni.2019.08.014.
The skin is densely innervated with nociceptive neurons specialized in detecting noxious and painful stimuli. In a recent issue of Cell, Cohen et al. report that activation of cutaneous nociceptive neurons leads to a nerve-reflex action that is sufficient to provide a danger signal that triggers regional immunity to fight a microbial challenge.
皮肤密布着专门用于检测有害和疼痛刺激的伤害性神经元。在最近一期的《Cell》杂志上，Cohen 等人报告称，激活皮肤伤害性神经元会导致神经反射作用，足以提供危险信号，触发区域免疫以抵抗微生物挑战。
