Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
J Am Acad Dermatol. 2014 Mar;70(3):517-24. doi: 10.1016/j.jaad.2013.10.044. Epub 2013 Dec 24.
Recent case-control studies observed an increased prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with psoriasis, which is relevant in selecting optimal psoriasis treatment.
We sought to compare the prevalence of NAFLD in people with psoriasis and those without psoriasis.
This large prospective population-based cohort study (part of the Rotterdam Study) enrolled elderly participants (>55 years). NAFLD was diagnosed as fatty liver on ultrasonography in the absence of other liver diseases. Participants with psoriasis were identified using a validated algorithm. Multivariable logistic regression model was used to assess whether psoriasis was associated with NAFLD after adjusting for demographic, lifestyle characteristics, and laboratory findings.
In total, 2292 participants were included (mean age 76.2 ± 6.0 years; 58.7% female; mean body mass index 27.4 ± 4.2kg/m(2)) of whom 118 (5.1%) had psoriasis. The prevalence of NAFLD was 46.2% in patients with psoriasis compared with 33.3% for the reference group without psoriasis (P = .005). Psoriasis was significantly associated with NAFLD; after adjustment for alcohol consumption, pack-years and smoking status, presence of metabolic syndrome, and alanine aminotransferase, psoriasis remained a significant predictor of NAFLD (adjusted odds ratio 1.7, 95% confidence interval 1.1-2.6).
This was a cross-sectional study.
Elderly participants with psoriasis are 70% more likely to have NAFLD than those without psoriasis independent of common NAFLD risk factors.
最近的病例对照研究观察到银屑病患者中非酒精性脂肪性肝病（NAFLD）的患病率增加，这与选择最佳银屑病治疗方法有关。
我们旨在比较银屑病患者和非银屑病患者中 NAFLD 的患病率。
这项大型前瞻性基于人群的队列研究（鹿特丹研究的一部分）纳入了老年参与者（>55 岁）。NAFLD 通过超声检查在无其他肝病的情况下诊断为脂肪肝。使用验证算法识别银屑病患者。多变量逻辑回归模型用于评估在调整人口统计学、生活方式特征和实验室发现后，银屑病是否与 NAFLD 相关。
共纳入 2292 名参与者（平均年龄 76.2 ± 6.0 岁；58.7%为女性；平均体重指数 27.4 ± 4.2kg/m²），其中 118 名（5.1%）患有银屑病。与无银屑病的参考组（33.3%）相比，银屑病患者的 NAFLD 患病率为 46.2%（P =.005）。银屑病与 NAFLD 显著相关；在调整饮酒量、吸烟状况、代谢综合征和丙氨酸氨基转移酶后，银屑病仍然是 NAFLD 的显著预测因素（调整后的优势比 1.7，95%置信区间 1.1-2.6）。
这是一项横断面研究。
独立于常见的 NAFLD 危险因素，老年银屑病患者发生 NAFLD 的可能性是非银屑病患者的 70%。
