André Nicole M, Cossic Brieuc, Davies Emma, Miller Andrew D, Whittaker Gary R
Department of Microbiology & Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.
Department of Biomedical Sciences, Section of Anatomic Pathology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.
JFMS Open Rep. 2019 Jun 26;5(1):2055116919856103. doi: 10.1177/2055116919856103. eCollection 2019 Jan-Jun.
This report describes a cat with chronic, progressive, non-painful, non-lateralizing multifocal neurologic clinical signs associated with feline infectious peritonitis (FIP). The cat initially presented as underweight, despite a good appetite, and a complete blood count showed non-regenerative anemia. Three months later the cat was returned having developed ataxia and paraparesis, which then progressed over 2 months to tetraparesis, tail plegia, urinary and fecal incontinence, and titubation. Histologic examination of the tissues with subsequent immunohistochemistry confirmed FIP-associated meningoencephalomyelitis following necropsy. Molecular analysis of the coronavirus spike protein within the tissues identified a specific, functionally relevant amino acid change (R793M), which was only identified in tissues associated with the central nervous system (ie, brain and spinal cord).
This case report describes an early presentation of a cat with primarily neurologic FIP, with molecular characterization of the virus within various tissues.
本报告描述了一只患有与猫传染性腹膜炎（FIP）相关的慢性、进行性、无痛性、无定位性多灶性神经临床症状的猫。这只猫最初表现为体重不足，尽管食欲良好，全血细胞计数显示为非再生性贫血。三个月后，这只猫因出现共济失调和轻截瘫而复诊，随后在两个月内进展为四肢瘫、尾部麻痹、大小便失禁和蹒跚步态。尸检后，对组织进行组织学检查并随后进行免疫组织化学检查，证实为与FIP相关的脑膜脑脊髓炎。对组织内冠状病毒刺突蛋白的分子分析确定了一个特定的、功能相关的氨基酸变化（R793M），该变化仅在与中枢神经系统相关的组织（即脑和脊髓）中发现。
本病例报告描述了一只主要表现为神经型FIP的猫的早期症状，并对不同组织中的病毒进行了分子特征分析。
