非抗酸分枝杆菌佐剂活性增强。

Elevated adjuvanticity of non-acid-fast mycobacteria.

作者信息

Kondo Y, Toida T

出版信息

Infect Immun. 1979 Oct;26(1):19-24. doi: 10.1128/iai.26.1.19-24.1979.

DOI:10.1128/iai.26.1.19-24.1979

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC414568/

Abstract

Administration to guinea pigs of non-acid-fast (NAF) Mycobacterium avium resulted in a sevenfold greater circulating antibody response than that for the animals receiving ovalbumin in Freund incomplete adjuvant alone. The ability of NAF M. avium on induction of delayed hypersensitivity was comparable or somewhat stronger than that of normal M. avium. The in vivo enhancement of circulating antibody response by NAF M. avium associated with a marked stimulating effect of it on proliferation of B cells in regional sites. Induction of local granuloma at the injection site of NAF M. avium was less than that induced by injection of normal M. avium. Phagocytic activity of the reticuloendothelial system in mice was also greatly increased by administration of NAF M. avium.

摘要

给豚鼠接种非抗酸（NAF）鸟分枝杆菌后，其循环抗体反应比仅接受弗氏不完全佐剂中卵清蛋白的动物高7倍。NAF鸟分枝杆菌诱导迟发型超敏反应的能力与正常鸟分枝杆菌相当或稍强。NAF鸟分枝杆菌对循环抗体反应的体内增强作用与其对局部区域B细胞增殖的显著刺激作用有关。NAF鸟分枝杆菌注射部位的局部肉芽肿形成比正常鸟分枝杆菌注射诱导的要少。给小鼠施用NAF鸟分枝杆菌也可大大提高网状内皮系统的吞噬活性。

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