头孢他啶-阿维巴坦成功治疗一名儿科重症患者的KPC-MDR败血症性休克。
Successful treatment of KPC-MDR septic shock with ceftazidime-avibactam in a pediatric critically ill patient.
作者信息
Vargas Maria, Buonomo Antonio Riccardo, Buonanno Pasquale, Iacovazzo Carmine, Servillo Giuseppe
机构信息
Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, Naples, Italy.
Department of Clinical Medicine and Surgery - Section of Infectious Diseases, University of Naples Federico II, Naples, Italy.
出版信息
IDCases. 2019 Sep 5;18:e00634. doi: 10.1016/j.idcr.2019.e00634. eCollection 2019.
Abstract
Ceftazidime-avibactam is a combination agent consisting of the β-lactamase inhibitor avibactam and the broad-spectrum cephalosporin ceftazidime. There are no published case reports or studies evaluating the use of CAZ-AVI in pediatric critically ill patients. We report a case of a successful treatment of septic shock due to (KP) in a 14-years-old boy (body weight 50 kg) admitted in intensive care unit (ICU).
摘要
头孢他啶-阿维巴坦是一种由β-内酰胺酶抑制剂阿维巴坦和广谱头孢菌素头孢他啶组成的复方制剂。目前尚无已发表的病例报告或研究评估头孢他啶-阿维巴坦在儿科重症患者中的应用。我们报告了一例在重症监护病房（ICU）收治的14岁男孩（体重50千克）因肺炎克雷伯菌（KP）导致的感染性休克成功治疗的病例。
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2
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Pediatr Infect Dis J. 2018 Jun;37(6):549-554. doi: 10.1097/INF.0000000000001859.
3
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Clin Microbiol Infect. 2011 Dec;17(12):1798-803. doi: 10.1111/j.1469-0691.2011.03514.x. Epub 2011 May 20.
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