Tiradentes University (UNIT), Aracaju, Brazil.
Health Sciences, Federal University of Sergipe, São Cristóvão, Brazil.
Games Health J. 2019 Oct;8(5):339-348. doi: 10.1089/g4h.2018.0066.
The progression of chronic kidney disease can directly affect patient's health-related quality of life (HRQoL). Exercise training is a good option to reverse the impacts caused by the disease. To escape from the monotonous routine and stimulate further practice, the therapist should consider making physical activity more playful. Using videogames during exercise training is possible to rehabilitate the patient aiming for fun beyond the organic condition. The present study aimed to evaluate the effects of exercise training combined with Virtual Reality (VR) in functionality and HRQoL of patients on hemodialysis. A randomized controlled study in which control group ( = 20) maintained only hemodialysis without any physical effort or intervention from the researchers and intervention group ( = 20) who performed endurance and strength physical exercises in combination with VR during hemodialysis for 12 weeks. All eligible patients underwent a familiarization of games and were evaluated by an investigator-blind for functional capacity, quality of life, and depressive symptoms. Functional capacity tests included walking speed, timed up and go (TUG), and Duke Activity Status Index (DASI). To evaluate a HRQoL, Kidney Disease and Quality-of-Life Short-Form (KDQOL-SF™, v. 1.3) was used and to investigate depressive symptoms, the Center for Epidemiological Scale-Depression. Paired sample -tests were conducted to determine differences within each group. Repeated-measures analysis of variance (group vs. time) was used to assess group differences in our major outcomes. The level of significance was 5%. The exercise improved functional capacity (TUG: = 0.002, DASI: < 0.001) and HRQoL in physical and specific domains: ( = 0.047), ( = 0.021), as well as in physical composite summary ( < 0.001) and ( = 0.013). There was no influence on depressive symptoms ( = 0.154). Physical training combined with VR improved functional capacity and some quality-of-life domains of hemodialysis patients.
慢性肾脏病的进展会直接影响患者的健康相关生活质量（HRQoL）。运动训练是逆转疾病影响的好方法。为了摆脱单调的常规并激发进一步的实践，治疗师应该考虑使体育活动更具趣味性。在运动训练中使用视频游戏可以使患者在超越有机状态的情况下获得乐趣，从而实现康复。本研究旨在评估运动训练与虚拟现实（VR）结合对血液透析患者功能和 HRQoL 的影响。
这是一项随机对照研究，其中对照组（n=20）仅维持血液透析，没有任何体力活动或研究人员的干预，而干预组（n=20）在血液透析期间进行耐力和力量运动锻炼，并结合 VR，共 12 周。所有符合条件的患者都进行了游戏的熟悉，由一名对功能能力、生活质量和抑郁症状不知情的研究者进行评估。功能能力测试包括步行速度、计时起立行走测试（TUG）和杜克活动状态指数（DASI）。为了评估生活质量，使用肾脏病和生活质量简表（KDQOL-SF™，v.1.3），为了调查抑郁症状，使用流行病学研究中心抑郁量表。进行配对样本 t 检验以确定每个组内的差异。重复测量方差分析（组间与时间）用于评估我们主要结局的组间差异。显著性水平为 5%。
运动改善了功能能力（TUG：p=0.002，DASI：p<0.001）和身体和特定领域的 HRQoL：（p=0.047），（p=0.021），以及身体综合摘要（p<0.001）和（p=0.013）。对抑郁症状没有影响（p=0.154）。
与 VR 结合的物理训练改善了血液透析患者的功能能力和一些生活质量领域。
