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肌肉萎缩症的扫描电子显微镜研究。

Scanning electron microscopy studies in muscular dystrophy.

作者信息

Miller S E, Roses A D, Appel S H

出版信息

Arch Neurol. 1976 Mar;33(3):172-4. doi: 10.1001/archneur.1976.00500030028005.

DOI:10.1001/archneur.1976.00500030028005
PMID:3154
Abstract

Scanning electron microscopy of unmanipulated erythrocytes from patients with myotonic dystrophy or Duchenne dystrophy and patients who were Duchenne carriers showed a large increase in the number of stomatocytes over the number in normal controls. No specific morhologic changes that would differentiate any of the dystrophic patients from one another were seen. Adverse conditions such as washing before fixation or extreme pH produced a greater change in erythrocytes from these patients than in those from normal controls.

摘要

对强直性肌营养不良患者、杜兴氏肌营养不良患者以及杜兴氏携带者的未经处理的红细胞进行扫描电子显微镜检查发现,与正常对照组相比,口形红细胞的数量大幅增加。未观察到能区分任何营养不良患者的特异性形态学变化。诸如固定前洗涤或极端pH值等不利条件对这些患者红细胞产生的变化比对正常对照组红细胞产生的变化更大。

相似文献

1
Scanning electron microscopy studies in muscular dystrophy.肌肉萎缩症的扫描电子显微镜研究。
Arch Neurol. 1976 Mar;33(3):172-4. doi: 10.1001/archneur.1976.00500030028005.
2
Morphological changes of erythrocytes in patients and carriers of Duchenne disease.杜兴氏病患者及携带者红细胞的形态学变化。
Acta Neurol Scand. 1983 Apr;67(4):242-4. doi: 10.1111/j.1600-0404.1983.tb04570.x.
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Electron spin resonance studies of erythrocytes from patients with Duchenne muscular dystrophy.杜兴氏肌营养不良症患者红细胞的电子自旋共振研究。
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Electron spin resonance investigations of membrane proteins in erythrocytes in muscle diseases. Duchenne and myotonic muscular dystrophy and congenital myotonia.肌肉疾病中红细胞膜蛋白的电子自旋共振研究。杜兴氏和强直性肌营养不良以及先天性肌强直。
Biochim Biophys Acta. 1977 Oct 3;470(1):1-7. doi: 10.1016/0005-2736(77)90056-6.
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Detection of carriers of human Duchenne muscular dystrophy by freeze-fracture analysis of erythrocyte plasmalemmal intramembrane particles.
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[Morphology and deformability of erythrocytes in muscular dystrophy].[肌肉萎缩症中红细胞的形态学与变形性]
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Erythrocyte deformation in human muscular dystrophy.
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Effect of exercise on serum creatine kinase in carriers of Duchenne muscular dystrophy.
运动对杜氏肌营养不良症携带者血清肌酸激酶的影响。
J Med Genet. 1982 Feb;19(1):4-7. doi: 10.1136/jmg.19.1.4.
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Cultured muscle from myotonic muscular dystrophy patients: altered membrane electrical properties.来自强直性肌营养不良患者的培养肌肉:膜电特性改变。
Proc Natl Acad Sci U S A. 1981 Jan;78(1):648-52. doi: 10.1073/pnas.78.1.648.
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Scanning electron microscopy studies of erythrocytes in spinocerebellar degeneration.脊髓小脑变性中红细胞的扫描电子显微镜研究。
J Neurol Neurosurg Psychiatry. 1984 Mar;47(3):269-74. doi: 10.1136/jnnp.47.3.269.
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Duchenne muscular dystrophy: pathogenetic aspects and genetic prevention.杜氏肌营养不良症:发病机制及基因预防
Hum Genet. 1984;66(1):17-40. doi: 10.1007/BF00275183.
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Neuronal degeneration in the brain of the brindled mouse. An ultrastructural study of the cerebral cortical neurons.斑驳小鼠大脑中的神经元变性。大脑皮质神经元的超微结构研究。
Acta Neuropathol. 1979 Jan 12;45(1):17-25. doi: 10.1007/BF00691800.
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Erythrocyte membrane abnormalities in Duchenne muscular dystrophy monitored by saturation transfer electron paramagnetic resonance spectroscopy.通过饱和转移电子顺磁共振波谱监测杜氏肌营养不良症中的红细胞膜异常。
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