Sleep and Health Promotion Laboratory, Mind, Brain and Behaviour Research Centre (CIMCYC), University of Granada, 18011 Granada, Spain.
EFFECTS-262 Research group, Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain.
Nutrients. 2019 Sep 15;11(9):2227. doi: 10.3390/nu11092227.
Obesity is a major risk factor for obstructive sleep apnoea (OSA), the most common sleep-disordered breathing related to neurocognitive and metabolic syndromes, type II diabetes, and cardiovascular diseases. Although strongly recommended for this condition, there are no studies on the effectiveness of an interdisciplinary weight loss and lifestyle intervention including nutrition, exercise, sleep hygiene, and smoking and alcohol cessation. INTERAPNEA is a randomised controlled trial with a two-arm parallel design aimed at determining the effects of an interdisciplinary tailored weight loss and lifestyle intervention on OSA outcomes. The study will include 84 males aged 18-65 with a body mass index of ≥25 kg/m and severe to moderate OSA randomly assigned to usual care (i.e., continuous positive airway pressure), or interdisciplinary weight loss and lifestyle intervention combined with usual care. Outcomes will be measured at baseline, intervention end-point, and six-month post-intervention, including apnoea-hypopnoea index (primary outcome), other neurophysical and cardiorespiratory polysomnographic outcomes, sleep quality, daily functioning and mood, body weight and composition, physical fitness, blood biomarkers, health-related quality of life, and cost-effectiveness. INTERAPNEA may serve to establish a cost-effective treatment not only for the improvement of OSA and its vast and severe comorbidities, but also for a potential remission of this condition.
肥胖是阻塞性睡眠呼吸暂停（OSA）的一个主要危险因素，OSA 是与神经认知和代谢综合征、二型糖尿病和心血管疾病相关的最常见睡眠呼吸障碍。尽管对于这种情况强烈推荐进行干预，但目前还没有关于包括营养、运动、睡眠卫生以及戒烟和戒酒在内的跨学科减肥和生活方式干预对 OSA 结局的有效性的研究。INTERAPNEA 是一项随机对照试验，采用两臂平行设计，旨在确定跨学科量身定制的减肥和生活方式干预对 OSA 结局的影响。该研究将纳入 84 名年龄在 18-65 岁之间、BMI≥25kg/m 和中重度 OSA 的男性，他们将被随机分配到常规护理（即持续气道正压通气）或跨学科减肥和生活方式干预联合常规护理组。在基线、干预终点和干预后 6 个月将测量结局，包括呼吸暂停-低通气指数（主要结局）、其他神经物理和心肺多导睡眠图结局、睡眠质量、日常功能和情绪、体重和成分、身体适应性、血液生物标志物、健康相关生活质量和成本效益。INTERAPNEA 可能有助于确定一种具有成本效益的治疗方法，不仅可以改善 OSA 及其广泛而严重的合并症，而且还可能使这种疾病得到缓解。
