Beck-Sickinger A G
Fakultät für Lebenswissenschaften, Institut für Biochemie, Universität Leipzig, Brüderstraße 34, 04103, Leipzig, Deutschland.
Internist (Berl). 2019 Oct;60(10):1014-1020. doi: 10.1007/s00108-019-00675-1.
Combinatorial procedures have become established in recent years as alternatives to rational design in drug research, particularly when no structural information is available. This article presents the principle that was originally developed by three scientists and was honored with the Nobel Prize for Chemistry in 2018. Furthermore, the application in the field of monclonal antibodies is discussed.
近年来，组合方法已成为药物研究中合理设计的替代方法，特别是在没有结构信息可用的情况下。本文介绍了最初由三位科学家开发并于2018年获得诺贝尔化学奖的原理。此外，还讨论了其在单克隆抗体领域的应用。
