巴布亚新几内亚东部高地的红细胞酶多态性

Red cell enzyme polymorphisms in Papua New Guinea Eastern Highlands.

作者信息

Seger J, Godelier M, Halle L, Lemonnier P, Lory J L, Rouger P, Ruffie J, Salmon D

机构信息

Institut National de Transfusion Sanguine, Etablissement Saint Antoine, Paris, France.

出版信息

Gene Geogr. 1988 Aug-Dec;2(2-3):99-106.

Abstract

Ten red cell enzyme polymorphisms, malic dehydrogenase (MDH1), adenylate kinase (AK), phosphohexose isomerase (PHI), adenosine deaminase (ADA), esterase D (ESD), glutamic pyruvic transaminase (GPT), acid phosphatase (ACP1), phosphoglucomutase 1 and 2 (PGM1, PGM2), phosphogluconate dehydrogenase (PGD) were investigated in the Baruya tribe and several Anga tribes living high in the Wonenara and Marawaka valleys in Papua New Guinea Eastern Highlands (6.5S, 145.5E). Also a non-Anga tribe, the Aziana or Kenaze, was sampled. Variants were observed in ADA, PGM1 and PGM2. AK and PHI were monomorphic, all subjects being AK 1 and PHI 1; MDH1 was also monomorphic in Anga while variants were observed in Aziana. This latter tribe differed markedly in each system from the Anga peoples.

摘要

在巴布亚新几内亚东部高地（南纬6.5度，东经145.5度）沃内纳拉和马拉瓦卡山谷高处生活的巴鲁亚部落以及几个安加部落中，研究了十种红细胞酶多态性，即苹果酸脱氢酶（MDH1）、腺苷酸激酶（AK）、磷酸己糖异构酶（PHI）、腺苷脱氨酶（ADA）、酯酶D（ESD）、谷丙转氨酶（GPT）、酸性磷酸酶（ACP1）、磷酸葡萄糖变位酶1和2（PGM1、PGM2）、磷酸葡萄糖酸脱氢酶（PGD）。还对一个非安加部落阿齐亚纳或凯纳泽进行了采样。在ADA、PGM1和PGM2中观察到了变体。AK和PHI是单态的，所有受试者均为AK 1和PHI 1；MDH1在安加人中也是单态的，而在阿齐亚纳人中观察到了变体。后一个部落在每个系统中与安加人有明显差异。

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