Iran University of Medical Sciences, Tehran, Iran.
Islamic Azad University of Medical Sciences, Sari, Iran.
J Cosmet Dermatol. 2020 May;19(5):1143-1145. doi: 10.1111/jocd.13125. Epub 2019 Sep 21.
Fixed Drug Eruption (FDE) is a drug reaction involving the skin and less commonly the mucosal membranes. Tamsulosin is an alpha-1 adrenergic receptor blocker used to treat benign prostatic hyperplasia. Dizziness and headache are among its most common side effects (Singapore Med J, 2018;59:336). Although cutaneous drug eruption has been reported with other alpha-1 adrenergic receptor blockers.
Drug rash due to Tamsulosin is relatively uncommon (Singapore Med J, 2018;59:336). In this case we report an incidence of fixed drug eruption due to Tamsulosin.
A 54 year old male, with benign prostatic hyperplasia was referred to our office for evaluation of certain eruptions, having developed his hyper-pigmented patches after 2 weeks of using oral 0.4 mg Tamsulosin per day. Based on the clinical course and the skin biopsy we diagnosed the condition as Tamsulosin associated fixed drug eruption. The most important therapeutic measure was discontinuing Tamsulosin medication. Following this, his eruptions improved remarkably in a few days without complications.
According to previous findings, there has been no case report on fixed drug eruption caused by Tamsulosin.
Our case is a relatively mild form of fixed drug eruption. Therefore it should be kept in mind that a severe cutaneous drug eruption might occur after Tamsulosin administration.
固定型药物疹（FDE）是一种涉及皮肤且较少累及黏膜的药物反应。坦索罗辛是一种用于治疗良性前列腺增生的α-1 肾上腺素能受体阻滞剂。头晕和头痛是其最常见的副作用之一（《新加坡医学杂志》，2018 年；59：336）。尽管已有其他 α-1 肾上腺素能受体阻滞剂引起的皮肤药物疹报道。
坦索罗辛引起的皮疹相对少见（《新加坡医学杂志》，2018 年；59：336）。在本案例中，我们报告了一例坦索罗辛引起的固定型药物疹。
一名 54 岁男性，因良性前列腺增生就诊，在每天口服 0.4 毫克坦索罗辛 2 周后，出现了色素沉着斑，我们的诊室对其进行了评估。根据临床病程和皮肤活检，我们诊断为坦索罗辛相关的固定型药物疹。最重要的治疗措施是停用坦索罗辛。停用坦索罗辛后，他的皮疹在几天内明显改善，无并发症。
根据既往研究结果，尚无坦索罗辛引起固定型药物疹的报道。
我们的病例为相对较轻的固定型药物疹。因此，在使用坦索罗辛后，可能会发生严重的皮肤药物疹，这一点应牢记在心。
