Department of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.
Department of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China.
Ecotoxicol Environ Saf. 2019 Dec 15;185:109684. doi: 10.1016/j.ecoenv.2019.109684. Epub 2019 Sep 18.
Bisphenol A (BPA) accumulates in patients with chronic kidney disease (CKD), and hemodialysis filters may contribute to bisphenol burden in patients on hemodialysis (HD). The serum levels of BPA and three BPA analogs, namely, bisphenol B (BPB), bisphenol S (BPS), and bisphenol F (BPF), in 58 patients with CKD, 66 patients on dialysis therapy and 30 healthy control were investigated. The content of four bisphenols (BPs) was also examined in three types of dialysis filters, followed by an in vitro elution experiment to test the release of BPs from the dialysis filters. The serum levels of BPA (r = -0.746, p < 0.05) and BPS (r = -0.433, p < 0.05) in 58 CKD patients and 30 healthy control were correlated with the decrease in estimated glomerular filtration rate. The serum levels of BPs in the HD patients were higher than those in the peritoneal dialysis patients (p < 0.05). In the in vitro study on the BP contents in dialysis filters, BPA was the main form of the BPs in the polysulfone membrane (20.86 ± 1.18 ng/mg) and in the polyamide membrane (18.70 ± 2.88 ng/mg), and a modicum of BPS (0.01 ± 0.01 ng/mg) was detected in the polyethersulfone membrane. The results of the elution experiment were in accordance with the results of BPs content in the dialysis filters. Insufficient renal function may lead to BPs accumulation in patients with CKD, and BPs in dialysis products may cause BPs burden in patients on HD.
双酚 A (BPA) 在慢性肾脏病 (CKD) 患者中蓄积，血液透析滤器可能会增加血液透析 (HD) 患者的双酚负担。本研究调查了 58 例 CKD 患者、66 例透析治疗患者和 30 名健康对照者的血清 BPA 及三种 BPA 类似物（双酚 B [BPB]、双酚 S [BPS]和双酚 F [BPF]）水平，还检测了三种透析滤器中的四种双酚（BPs）含量，并进行了体外洗脱实验以检测 BPs 从透析滤器中的释放情况。58 例 CKD 患者和 30 名健康对照者的血清 BPA（r=−0.746，p<0.05）和 BPS（r=−0.433，p<0.05）水平与估算肾小球滤过率的下降呈负相关。HD 患者的血清 BPs 水平高于腹膜透析患者（p<0.05）。在透析滤器中 BP 含量的体外研究中，BPA 是聚砜膜（20.86±1.18ng/mg）和聚酰胺膜（18.70±2.88ng/mg）中 BPs 的主要形式，聚醚砜膜中检测到少量的 BPS（0.01±0.01ng/mg）。洗脱实验的结果与透析滤器中 BPs 含量的结果一致。肾功能不全可能导致 CKD 患者的 BPs 蓄积，透析产品中的 BPs 可能会增加 HD 患者的 BPs 负担。
