Nephrology Department, Hospital Universitario de la Princesa, 28806 Madrid, Spain.
Biomolecules. 2021 Sep 17;11(9):1375. doi: 10.3390/biom11091375.
Bisphenol A (BPA), also known as 2,2,-bis(4-hydroxyphenyl) propane, is a common component of plastics worldwide. However, it has been shown to act as an endocrine disruptor with some hormonal functions. Furthermore, high levels of BPA have been related to the development of cardiovascular events and the activation of carcinogenesis pathways. Patients with chronic kidney disease (CKD) have higher serum concentrations of BPA due to their impaired renal function. This situation is aggravated in CKD patients requiring dialysis, because the BPA content of dialysis devices (such as, for example, the filters) is added to the lack of excretion. In addition to the development of BPA-free dialysis filters, some techniques can contribute to the reduction of BPA levels in these patients. The aim of this review is to illustrate the impact of BPA on dialysis patients and suggest some strategies to reduce its inherent risks.
双酚 A（BPA），也称为 2,2-双（4-羟基苯基）丙烷，是世界范围内塑料的常见成分。然而，它已被证明具有内分泌干扰物的作用，具有一些激素功能。此外，高水平的 BPA 与心血管事件的发展和致癌途径的激活有关。由于肾功能受损，慢性肾脏病（CKD）患者的血清 BPA 浓度更高。在需要透析的 CKD 患者中，这种情况会加剧，因为透析设备（例如过滤器）中的 BPA 含量会增加排泄不足。除了开发无 BPA 透析过滤器外，一些技术还可以有助于降低这些患者的 BPA 水平。本综述的目的是说明 BPA 对透析患者的影响，并提出一些降低其固有风险的策略。
