Balić Anamaria, Vlašić Domagoj, Mokos Mislav, Marinović Branka
Professor Branka Marinović, MD, PhD, Department of Dermatology and Venereology, University Hospital Centre Zagreb, School of Medicine University of Zagreb, 10000 Zagreb, Croatia;
Acta Dermatovenerol Croat. 2019 Sep;27(3):169-179.
Periorificial dermatitis, mostly known as perioral dermatitis, is a benign inflammatory facial dermatosis which can be a severe burden and even disfiguring and psychologically disturbing. The disease still presents a challenge for physicians when it comes to etiology and appropriate therapy. Although a variety of extrinsic and intrinsic factors have been proposed as etiopathogenetic factors, none of these fully explain complex pathogenesis of the disease. There is more evidence that supports beliefs that the epidermal barrier dysfunction is an underlying main pathogenic factor that contributes to persistent cutaneous inflammation in typical facial localizations. Patients with periorificial dermatitis are considered hyper-reactors who have impaired essential function of the skin barrier, especially the skin barrier of the perioral region, characterized by thin permeable stratum corneum and imbalance of intercellular lipids, which makes them more susceptible to various internal and external irritants that contribute to the development of the disease. The verification of this connection reinforces the need for clinicians to address this issue when approaching their patients and formulating the best treatment plan. Treatment should emphasize repairing the impaired skin barrier function to minimize associated skin inflammation and sensitivity, which results in resolution of the objective and subjective symptoms.
口周皮炎，大多称为口周皮肤炎，是一种良性炎症性面部皮肤病，可能会造成严重负担，甚至毁容并引起心理困扰。在病因和适当治疗方面，这种疾病对医生来说仍然是一个挑战。尽管已提出多种外在和内在因素作为病因，但这些因素均无法完全解释该疾病复杂的发病机制。有更多证据支持这样的观点，即表皮屏障功能障碍是导致典型面部部位持续性皮肤炎症的潜在主要致病因素。口周皮炎患者被认为是高反应者，其皮肤屏障的基本功能受损，尤其是口周区域的皮肤屏障，其特征是角质层薄且渗透性强，细胞间脂质失衡，这使得他们更容易受到各种内外刺激物的影响，从而导致疾病的发生。这种关联的证实强化了临床医生在诊治患者并制定最佳治疗方案时应对这一问题的必要性。治疗应着重修复受损的皮肤屏障功能，以尽量减少相关的皮肤炎症和敏感性，从而消除客观和主观症状。
