The University of Queensland, Queensland Alliance for Environmental Health Sciences (QAEHS), 20 Cornwall Street, Woolloongabba, QLD, 4102, Australia.
The University of Queensland, Queensland Alliance for Environmental Health Sciences (QAEHS), 20 Cornwall Street, Woolloongabba, QLD, 4102, Australia.
Water Res. 2019 Dec 1;166:115068. doi: 10.1016/j.watres.2019.115068. Epub 2019 Sep 9.
Wastewater contains a wealth of information about the population who contribute to it including biological and chemical markers of human activity and exposures. F-isoprostanes have been proposed as oxidative stress biomarkers that can be measured in wastewater to provide a measure of oxidative stress at the population level. While an association between tobacco use and their level in wastewater has been demonstrated, an in-sewer stability assessment has not been conducted to support their use as oxidative stress biomarkers for wastewater-based epidemiology studies. In this study we investigated the stability of 8-iso-prostaglandin F (PGF), its metabolite dinor-11β-Prostaglandin F (dnPGF) and Prostaglandin E (PGE) (representative of other classes of prostaglandins) in laboratory-scale sewer reactors simulating real sewers. PGF, dnPGF and PGE were all found to be sufficiently stable under typical sewer conditions therefore satisfying the stability requirement of wastewater-based epidemiology population health biomarkers.
污水中包含了大量有关其来源人群的信息，包括人类活动和暴露的生物和化学标志物。F-型异前列烷被提议作为氧化应激生物标志物，可以在污水中进行测量，以提供人群水平氧化应激的衡量指标。虽然已经证明了吸烟与它们在污水中的水平之间存在关联，但尚未进行下水道内稳定性评估来支持将其用作基于污水的流行病学研究中的氧化应激生物标志物。在这项研究中，我们研究了 8-异前列腺素 F (PGF)、其代谢物二氢-11β-前列腺素 F (dnPGF) 和前列腺素 E (PGE)（代表其他类别的前列腺素）在模拟真实下水道的实验室规模下水道反应器中的稳定性。在典型的下水道条件下，发现 PGF、dnPGF 和 PGE 都足够稳定，因此满足了基于污水的流行病学人群健康生物标志物的稳定性要求。
